West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles

• Published in: BMC genomics Vol. 20; no. 1; pp. 474 - 21
• Main Authors: Slonchak, Andrii, Clarke, Brian, Mackenzie, Jason, Amarilla, Alberto Anastacio, Setoh, Yin Xiang, Khromykh, Alexander A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.06.2019; BioMed Central; BMC
• Subjects: Acids; Animals; Antisense RNA; Antiviral agents; Antiviral state; Bioinformatics; Biological response modifiers; Care and treatment; Cargo; Cell Line; Chemical composition; Criminal investigation; Cytokines; Encephalitis; Exosomes; Extracellular vesicles; Extracellular Vesicles - drug effects; Extracellular Vesicles - genetics; Flavivirus; Gene expression; Gene Expression Profiling; Gene sequencing; Genetic aspects; Genomics; Hepatitis; Humans; Infection; Infections; Inflammation; Interferon; Interferon alpha; Interferon-alpha - pharmacology; Membrane vesicles; Messenger RNA; MicroRNA; MicroRNAs - metabolism; miRNA; Next-generation sequencing; Proteins; Ribonucleic acid; RNA; RNA polymerase; RNA sequencing; RNA, Messenger - metabolism; RNA, Small Untranslated - metabolism; Signal transduction; snoRNA; Vector-borne diseases; Vesicles; Virus diseases; Viruses; West Nile fever; West Nile virus; West Nile virus - physiology; α-Interferon; Japan; Noncoding RNA; West Nile virus; Extracellular vesicles; miRNA; Exosomes; Flavivirus; snoRNA

Extracellular vesicles (EVs) are small membrane vesicles secreted by the cells that mediate intercellular transfer of molecules and contribute to transduction of various signals. Viral infection and action of pro-inflammatory cytokines has been shown to alter molecular composition of EV content. Tra...