Repair of DNA: Polypeptide Crosslinks by Human Excision Nuclease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 11; pp. 4056 - 4061
• Main Authors: Reardon, Joyce T., Sancar, Aziz
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.03.2006; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Animals; Base Sequence; Biochemistry; Biological Sciences; CHO Cells; Cricetinae; Cross-Linking Reagents; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; DNA - metabolism; DNA damage; DNA repair; DNA Repair - physiology; DNA Repair Enzymes - chemistry; DNA Repair Enzymes - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Enzymes; Escherichia coli - enzymology; Gels; HeLa Cells; Human subjects; Humans; In Vitro Techniques; Kinetics; Lesions; Models, Biological; Peptides; Peptides - chemistry; Peptides - metabolism; Plasmids; Protein Subunits; Substrate Specificity; Xeroderma Pigmentosum Group A Protein - chemistry; Xeroderma Pigmentosum Group A Protein - metabolism
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.0600538103

DNA-protein crosslinks are relatively common DNA lesions that form during the physiological processing of DNA by replication and recombination proteins, by side reactions of base excision repair enzymes, and by cellular exposure to bifunctional DNA-damaging agents such as platinum compounds. The mec...