Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice

• Published in: BMC pharmacology & toxicology Vol. 24; no. 1; p. 9
• Main Authors: ElShebiney, Shaimaa A, Elgohary, Rania, Kenawy, Sayed H, El-Bassyouni, Gehan T, Hamzawy, Esmat M A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.02.2023; BioMed Central; BMC
• Subjects: Acute intoxication; Adsorption; Analgesics, Opioid - adverse effects; Animals; Antidote; Benzodiazepines; Calcium; Calcium Compounds; Calcium oxide; Calcium silicates; Composite materials; Convulsions & seizures; Detoxification; Diazepam; Drug delivery systems; Drug dosages; Ferric oxide; Hematite; Intoxication; Iron compounds; Iron oxides; Laboratory animals; Mice; Nano-microstructure; Nitrates; Scanning electron microscopy; Seizures; Seizures (Medicine); Seizures - chemically induced; Seizures - drug therapy; Silica; Silicate phases; Toxicity; Toxicity management; Tramadol; Wollastonite; Zinc oxide; Zinc Oxide - toxicity; Zinc oxides; Egypt; Germany; Wollastonite; Nano-microstructure; Adsorption; Antidote; Silicate phases; Toxicity management

Seizures are considered to be the most common symptom encountered in emergency- rushed tramadol-poisoned patients; accounting for 8% of the drug-induced seizure cases. Although, diazepam clears these seizures, the risk of central respiratory depression cannot be overlooked. Henceforth, three adsorbi...