Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

• Published in: Psychopharmacologia Vol. 199; no. 1; pp. 109 - 117
• Main Authors: Richards, Jemma K., Simms, Jeffrey A., Steensland, Pia, Taha, Sharif A., Borgland, Stephanie L., Bonci, Antonello, Bartlett, Selena E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2008; Springer; Springer Nature B.V
• Subjects: Adrenergic alpha-Antagonists - pharmacology; Alcoholism - physiopathology; Animal behavior; Animals; Benzoxazoles - pharmacology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Conditioning, Operant - drug effects; Dose-Response Relationship, Drug; Ethanol; Extinction, Psychological - drug effects; Food; Male; Medical sciences; Motivation; Motor Activity - drug effects; Neurosciences; Neurotransmitters; Orexin Receptors; Original Investigation; Pharmacology/Toxicology; Psychiatry; Psychopharmacology; Psychotropic drugs; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled - antagonists & inhibitors; Receptors, Neuropeptide - antagonists & inhibitors; Rodents; Self Administration; Sucrose - administration & dosage; Sugar; Taste - drug effects; Taste - physiology; Urea - analogs & derivatives; Urea - pharmacology; Yohimbine - pharmacology; Operant self administration; Yohimbine; Ethanol; Reinstatement; Orexin; Hypocretin; Stress; SB334867; α2-Adrenergic receptor; Rat; Sucrose; Rodentia; Instrumental conditioning; Self administration; Neuropeptide; Vertebrata; Mammalia; Animal; Antagonist; Inhibition

Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and...