Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and...

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Published inPsychopharmacologia Vol. 199; no. 1; pp. 109 - 117
Main Authors Richards, Jemma K., Simms, Jeffrey A., Steensland, Pia, Taha, Sharif A., Borgland, Stephanie L., Bonci, Antonello, Bartlett, Selena E.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.07.2008
Springer
Springer Nature B.V
Subjects
Adrenergic alpha-Antagonists - pharmacology
Alcoholism - physiopathology
Animal behavior
Animals
Benzoxazoles - pharmacology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Ethanol
Extinction, Psychological - drug effects
Food
Male
Medical sciences
Motivation
Motor Activity - drug effects
Neurosciences
Neurotransmitters
Orexin Receptors
Original Investigation
Pharmacology/Toxicology
Psychiatry
Psychopharmacology
Psychotropic drugs
Rats
Rats, Long-Evans
Receptors, G-Protein-Coupled - antagonists & inhibitors
Receptors, Neuropeptide - antagonists & inhibitors
Rodents
Self Administration
Sucrose - administration & dosage
Sugar
Taste - drug effects
Taste - physiology
Urea - analogs & derivatives
Urea - pharmacology
Yohimbine - pharmacology
Operant self administration
Yohimbine
Ethanol
Reinstatement
Orexin
Hypocretin
Stress
SB334867
α2-Adrenergic receptor
Rat
Sucrose
Rodentia
Instrumental conditioning
Self administration
Neuropeptide
Vertebrata
Mammalia
Animal
Antagonist
Inhibition
Online AccessGet full text

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Abstract Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Materials and methods Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. Results The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. Conclusions The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
AbstractList Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking.RATIONALEPrevious studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking.Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test.MATERIALS AND METHODSRats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test.The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test.RESULTSThe orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test.The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.CONCLUSIONSThe results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Materials and methods Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. Results The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. Conclusions The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
Rationale: Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Materials and methods: Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. Results: The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. Conclusions: The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats. [PUBLICATION ABSTRACT]
Author Richards, Jemma K.
Bartlett, Selena E.
Taha, Sharif A.
Borgland, Stephanie L.
Steensland, Pia
Bonci, Antonello
Simms, Jeffrey A.
Author_xml – sequence: 1
  givenname: Jemma K.
  surname: Richards
  fullname: Richards, Jemma K.
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 2
  givenname: Jeffrey A.
  surname: Simms
  fullname: Simms, Jeffrey A.
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 3
  givenname: Pia
  surname: Steensland
  fullname: Steensland, Pia
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 4
  givenname: Sharif A.
  surname: Taha
  fullname: Taha, Sharif A.
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 5
  givenname: Stephanie L.
  surname: Borgland
  fullname: Borgland, Stephanie L.
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 6
  givenname: Antonello
  surname: Bonci
  fullname: Bonci, Antonello
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
– sequence: 7
  givenname: Selena E.
  surname: Bartlett
  fullname: Bartlett, Selena E.
  email: selenab@gallo.ucsf.edu
  organization: Ernest Gallo Clinic and Research Center, University of California San Francisco
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20476123$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18470506$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Operant self administration
Yohimbine
Ethanol
Reinstatement
Orexin
Hypocretin
Stress
SB334867
α2-Adrenergic receptor
Rat
Sucrose
Rodentia
Instrumental conditioning
Self administration
Neuropeptide
Vertebrata
Mammalia
Animal
Antagonist
Inhibition
Language English
License CC BY 4.0
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SourceType-Scholarly Journals-1
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content type line 14
content type line 23
Principal Editor: Klaus A. Miczek, Ph.D.
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PMID 18470506
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Snippet Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and...
Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol...
Rationale: Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and...
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pubmed
pascalfrancis
crossref
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SourceType Open Access Repository
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StartPage 109
SubjectTerms Adrenergic alpha-Antagonists - pharmacology
Alcoholism - physiopathology
Animal behavior
Animals
Benzoxazoles - pharmacology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Ethanol
Extinction, Psychological - drug effects
Food
Male
Medical sciences
Motivation
Motor Activity - drug effects
Neurosciences
Neurotransmitters
Orexin Receptors
Original Investigation
Pharmacology/Toxicology
Psychiatry
Psychopharmacology
Psychotropic drugs
Rats
Rats, Long-Evans
Receptors, G-Protein-Coupled - antagonists & inhibitors
Receptors, Neuropeptide - antagonists & inhibitors
Rodents
Self Administration
Sucrose - administration & dosage
Sugar
Taste - drug effects
Taste - physiology
Urea - analogs & derivatives
Urea - pharmacology
Yohimbine - pharmacology
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Title Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats
URI https://link.springer.com/article/10.1007/s00213-008-1136-5
https://www.ncbi.nlm.nih.gov/pubmed/18470506
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https://www.proquest.com/docview/20826462
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https://pubmed.ncbi.nlm.nih.gov/PMC2668563
Volume 199
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