Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups

• Published in: NeuroImage (Orlando, Fla.) Vol. 47; no. 4; pp. 1678 - 1690
• Main Authors: Fleisher, Adam S., Sherzai, Ayesha, Taylor, Curtis, Langbaum, Jessica B.S., Chen, Kewei, Buxton, Richard B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2009; Elsevier Limited
• Subjects: Aged; Algorithms; Alzheimer Disease - diagnosis; Alzheimer's disease; APOE4; Brain; Default network; Diagnosis, Differential; Evoked Potentials; Female; fMRI; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Middle Aged; Nerve Net; NMR; Nuclear magnetic resonance; Older people; Reproducibility of Results; Rest; Risk Assessment; Risk Factors; Sensitivity and Specificity; Task Performance and Analysis; Default network; fMRI; Alzheimer's disease; APOE4

To assess the ability of resting-state functional magnetic resonance imaging to distinguish known risk factors for AD, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the apolipoprotein e4 allele compared to 12 individuals who were not carriers of...