Overexpression of Alternatively Spliced Tissue Factor Induces the Pro-Angiogenic Properties of Murine Cardiomyocytic HL-1 Cells

• Published in: Circulation Journal Vol. 75; no. 5; pp. 1235 - 1242
• Main Authors: Eisenreich, Andreas, Boltzen, Ulrike, Malz, Ronny, Schultheiss, Heinz-Peter, Rauch, Ursula
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2011
• Subjects: Alternative Splicing; Alternatively spliced tissue factor; Angiogenesis; Angiogenesis Inducing Agents; Animals; Cell Line; Cell Movement; Cell Proliferation; Chemokines; Gene Expression; Growth; Mice; Migration; Myocytes, Cardiac - cytology; Myocytes, Cardiac - physiology; Neovascularization, Physiologic; Thromboplastin - genetics

Background: Tissue factor (TF) is expressed in 2 isoforms: membrane-bound "full length" (fl)TF and soluble alternatively spliced (as)TF. flTF is the major thrombogenic form of TF. Although the function of asTF is poorly understood, it was suggested that asTF contributes to tumor-associated...