Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

• Published in: Molecular autism Vol. 11; no. 1; p. 99
• Main Authors: Cheffer, Arquimedes, Flitsch, Lea Jessica, Krutenko, Tamara, Röderer, Pascal, Sokhranyaeva, Liubov, Iefremova, Vira, Hajo, Mohamad, Peitz, Michael, Schwarz, Martin Karl, Brüstle, Oliver
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.12.2020; BioMed Central; BMC
• Subjects: Animals; Autism; Autism spectrum disorder; Autism Spectrum Disorder - pathology; Autism Spectrum Disorder - physiopathology; Brain; Brain organoids; Cell reprogramming; Cellular Reprogramming - genetics; Humans; In vitro differentiation; Induced pluripotent stem cells; Induced Pluripotent Stem Cells - pathology; Models, Biological; Mutation; Neurodevelopmental disorders; Neuronal connectivity; Neurons - pathology; Nuclear reprogramming; Organoids - pathology; Review; Stem cells; Germany; Cell reprogramming; Induced pluripotent stem cells; Brain organoids; Autism spectrum disorder; In vitro differentiation; Neuronal connectivity

The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a unique opportunity to study early stages of human central nervous system development under controlled conditions in vitro. With the advent of cell reprogramming and the possibility to generate induced plur...