Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

• Published in: Skeletal muscle Vol. 7; no. 1; pp. 23 - 15
• Main Authors: Wada, Eiji, Tanihata, Jun, Iwamura, Akira, Takeda, Shin’ichi, Hayashi, Yukiko K., Matsuda, Ryoichi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.10.2017; BioMed Central; BMC
• Subjects: Animal models; Arthritis; Cardiac muscle; Care and treatment; Creatine; Creatine kinase; Cytokines; Degeneration; Diaphragm; Disease; Drug dosages; Duchenne muscular dystrophy; Duchenne's muscular dystrophy; Dystrophin; Embryos; Fibrosis; Health aspects; Immunoglobulin G; Inflammation; Inflammatory diseases; Interleukin 6; Interleukin 6 receptors; Kyphosis; Metabolism; Muscle regeneration; Muscular dystrophy; Musculoskeletal system; Myosin; Pathology; Physiological aspects; Quadriceps muscle; Rats; Rodents; Skeletal muscle; STAT3; Stem cells; Tissue engineering; Transcription; Transgenic animals; Utrophin; Vertebrae; Duchenne muscular dystrophy; Muscle regeneration; Fibrosis; STAT3; Interleukin-6

Chronic increases in the levels of the inflammatory cytokine interleukin-6 (IL-6) in serum and skeletal muscle are thought to contribute to the progression of muscular dystrophy. Dystrophin/utrophin double-knockout (dKO) mice develop a more severe and progressive muscular dystrophy than the mdx mice...