Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes

• Published in: Human genetics Vol. 133; no. 9; pp. 1093 - 1104
• Main Authors: Zhang, Huiping, Wang, Fan, Kranzler, Henry R., Yang, Can, Xu, Hongqin, Wang, Zuoheng, Zhao, Hongyu, Gelernter, Joel
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2014; Springer; Springer Nature B.V
• Subjects: African Americans; African Americans - genetics; Alcohol; Alcoholic beverages; Alcoholism; Alcoholism - ethnology; Alcoholism - genetics; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Computational Biology; CpG Islands - genetics; DNA; DNA Methylation; European Continental Ancestry Group - genetics; Female; Gene expression; Gene Function; Genes; Genetic Association Studies - methods; Genomes; Genomics; Genotype; Human Genetics; Humans; Male; Medicine; Metabolic Diseases; Methylation; Molecular Medicine; Neurosciences; Original Investigation; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Psychiatry; Quantitative genetics; Quantitative Trait Loci - genetics; Risk Factors; United States > US; Alcohol Dependence Subject; Alcohol Dependence; Unique SNPs; Methylation Quantitative Trait Locus; Ancestry Proportion

Interaction of DNA methylation and sequence variants that are methylation quantitative trait loci (mQTLs) may influence susceptibility to diseases such as alcohol dependence (AD). We used genome-wide genotype data from 268 African Americans (AAs: 129 AD cases and 139 controls) and 143 European Ameri...