The effects of common structural variants on 3D chromatin structure

• Published in: BMC genomics Vol. 21; no. 1; pp. 95 - 10
• Main Authors: Shanta, Omar, Noor, Amina, Sebat, Jonathan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.01.2020; BioMed Central; BMC
• Subjects: Breakpoints; Cell Line, Tumor; Chromatin; Chromatin - chemistry; Chromatin - genetics; Chromatin Assembly and Disassembly; Chromosomes; Chromosomes, Human - chemistry; Chromosomes, Human - genetics; Clonal deletion; Conformation; Deletion; DNA sequencing; Enhancer Elements, Genetic; Genes; Genetic aspects; Genetic factors; Genomes; Genomic Structural Variation; Genomics; Hi-C; Human populations; Humans; Inversion; Inversions; Linear Models; Lymphoblastoid cell lines; Methods; Regression analysis; Regulatory sequences; Sequence Deletion; Sequence Inversion; Structural variation; Structure; Structure (Literature); TAD; TAD fusion; Ultrasonic testing; United States; Chromatin; Hi-C; TAD; Structural variation; Deletion; TAD fusion; Inversion

Three-dimensional spatial organization of chromosomes is defined by highly self-interacting regions 0.1-1 Mb in size termed Topological Associating Domains (TADs). Genetic factors that explain dynamic variation in TAD structure are not understood. We hypothesize that common structural variation (SV)...