Sorbitol and lactitol reduce body fat and toxic ammonia levels in rats

Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or 7% lactitol on nutrient metabolism in cecectomized (CTx) and normal rats. After 16 days of feeding with the experimental diets, food intake...

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Published inNutrition Research Vol. 27; no. 7; pp. 440 - 447
Main Authors Shahidul Islam, M., Nishiyama, Ayae, Sakaguchi, Ei
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.07.2007
Elsevier BV
Elsevier Science
Subjects
Ammonia
ammonium nitrogen
animal models
Biological and medical sciences
blood serum
blood urea nitrogen
Body fat
experimental diets
fatty liver
Feeding. Feeding behavior
food intake
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
gut ammonia nitrogen
health promotion
hepatoprotective effect
Lactitol
lipemic effect
lipolysis
metabolic detoxification
nutrient partitioning
Rat
rats
Sorbitol
Sugar alcohols
urea nitrogen
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Sorbitol
Ammonia
Sugar alcohols
Body fat
Rat
Lactitol
Rodentia
Alcohol
Vertebrata
Mammalia
Animal
Fat
Sugar
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Abstract Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or 7% lactitol on nutrient metabolism in cecectomized (CTx) and normal rats. After 16 days of feeding with the experimental diets, food intake was not significantly different, but body weight was significantly decreased in the lactitol-fed groups compared with their respective control groups. The concentration and accumulation of fat in the carcass and the concentration of gut ammonia nitrogen were significantly decreased in both groups of rats fed SAs, and these effects were significantly higher ( P < .05) in CTx rats than in normal rats. Blood urea nitrogen concentration was significantly decreased in the SA-fed groups compared with their control group of normal rats. Lactitol, but not sorbitol, significantly decreased the rate of protein accumulation and the concentration of blood urea nitrogen, respectively, in normal and CTx rats. These data suggest that sorbitol and lactitol can reduce body fat as well as fatty liver condition. Moreover, lactitol is more effective in reducing the parameters studied, which are major risk factors associated with chronic hepatic encephalopathy.
AbstractList Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or 7% lactitol on nutrient metabolism in cecectomized (CTx) and normal rats. After 16 days of feeding with the experimental diets, food intake was not significantly different, but body weight was significantly decreased in the lactitol-fed groups compared with their respective control groups. The concentration and accumulation of fat in the carcass and the concentration of gut ammonia nitrogen were significantly decreased in both groups of rats fed SAs, and these effects were significantly higher (P < .05) in CTx rats than in normal rats. Blood urea nitrogen concentration was significantly decreased in the SA-fed groups compared with their control group of normal rats. Lactitol, but not sorbitol, significantly decreased the rate of protein accumulation and the concentration of blood urea nitrogen, respectively, in normal and CTx rats. These data suggest that sorbitol and lactitol can reduce body fat as well as fatty liver condition. Moreover, lactitol is more effective in reducing the parameters studied, which are major risk factors associated with chronic hepatic encephalopathy.
Abstract Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or 7% lactitol on nutrient metabolism in cecectomized (CTx) and normal rats. After 16 days of feeding with the experimental diets, food intake was not significantly different, but body weight was significantly decreased in the lactitol-fed groups compared with their respective control groups. The concentration and accumulation of fat in the carcass and the concentration of gut ammonia nitrogen were significantly decreased in both groups of rats fed SAs, and these effects were significantly higher ( P < .05) in CTx rats than in normal rats. Blood urea nitrogen concentration was significantly decreased in the SA-fed groups compared with their control group of normal rats. Lactitol, but not sorbitol, significantly decreased the rate of protein accumulation and the concentration of blood urea nitrogen, respectively, in normal and CTx rats. These data suggest that sorbitol and lactitol can reduce body fat as well as fatty liver condition. Moreover, lactitol is more effective in reducing the parameters studied, which are major risk factors associated with chronic hepatic encephalopathy.
Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or 7% lactitol on nutrient metabolism in cecectomized (CTx) and normal rats. After 16 days of feeding with the experimental diets, food intake was not significantly different, but body weight was significantly decreased in the lactitol-fed groups compared with their respective control groups. The concentration and accumulation of fat in the carcass and the concentration of gut ammonia nitrogen were significantly decreased in both groups of rats fed SAs, and these effects were significantly higher ( P < .05) in CTx rats than in normal rats. Blood urea nitrogen concentration was significantly decreased in the SA-fed groups compared with their control group of normal rats. Lactitol, but not sorbitol, significantly decreased the rate of protein accumulation and the concentration of blood urea nitrogen, respectively, in normal and CTx rats. These data suggest that sorbitol and lactitol can reduce body fat as well as fatty liver condition. Moreover, lactitol is more effective in reducing the parameters studied, which are major risk factors associated with chronic hepatic encephalopathy.
Author Shahidul Islam, M.
Nishiyama, Ayae
Sakaguchi, Ei
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Issue 7
Keywords Sorbitol
Ammonia
Sugar alcohols
Body fat
Rat
Lactitol
Rodentia
Alcohol
Vertebrata
Mammalia
Animal
Fat
Sugar
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Snippet Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7% sorbitol or...
Abstract Sugar alcohols (SAs) are widely used in various food products because of their benefits on health. The present study investigated the effects of 7%...
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SubjectTerms Ammonia
ammonium nitrogen
animal models
Biological and medical sciences
blood serum
blood urea nitrogen
Body fat
experimental diets
fatty liver
Feeding. Feeding behavior
food intake
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
gut ammonia nitrogen
health promotion
hepatoprotective effect
Lactitol
lipemic effect
lipolysis
metabolic detoxification
nutrient partitioning
Rat
rats
Sorbitol
Sugar alcohols
urea nitrogen
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Title Sorbitol and lactitol reduce body fat and toxic ammonia levels in rats
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https://cir.nii.ac.jp/crid/1873116918022589696
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Volume 27
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