Oxidative Stress in Stem Cell Aging

• Published in: Cell transplantation Vol. 26; no. 9; pp. 1483 - 1495
• Main Authors: Chen, Feng, Liu, Yingxia, Wong, Nai-Kei, Xiao, Jia, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.09.2017; Sage Publications Ltd; SAGE Publishing
• Subjects: Aging; Antioxidants; Apoptosis; Carbohydrates; Homeostasis; Lipids; Macromolecules; Original; Oxidative stress; Reactive oxygen species; Senescence; Stem cells; Transplantation; signaling pathway; aging; stem cell; oxidative stress; transplantation

Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nuclei...