Oxidative Stress in Stem Cell Aging

Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nuclei...

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Published inCell transplantation Vol. 26; no. 9; pp. 1483 - 1495
Main Authors Chen, Feng, Liu, Yingxia, Wong, Nai-Kei, Xiao, Jia, So, Kwok-Fai
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.2017
Sage Publications Ltd
SAGE Publishing
Subjects
Aging
Antioxidants
Apoptosis
Carbohydrates
Homeostasis
Lipids
Macromolecules
Original
Oxidative stress
Reactive oxygen species
Senescence
Stem cells
Transplantation
signaling pathway
aging
stem cell
oxidative stress
transplantation
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Abstract Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed.
AbstractList Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed.
Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed.Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed.
Author Chen, Feng
So, Kwok-Fai
Liu, Yingxia
Wong, Nai-Kei
Xiao, Jia
AuthorAffiliation 1 State Key Discipline of Infectious Diseases and Chemical Biology Laboratory for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, China
2 Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China
3 GMH Institute of CNS Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China
AuthorAffiliation_xml – name: 2 Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China
– name: 3 GMH Institute of CNS Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China
– name: 1 State Key Discipline of Infectious Diseases and Chemical Biology Laboratory for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, China
Author_xml – sequence: 1
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– sequence: 3
  givenname: Nai-Kei
  surname: Wong
  fullname: Wong, Nai-Kei
– sequence: 4
  givenname: Jia
  surname: Xiao
  fullname: Xiao, Jia
  email: tjxiao@jnu.edu.cn
– sequence: 5
  givenname: Kwok-Fai
  surname: So
  fullname: So, Kwok-Fai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29113471$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.cub.2005.07.035
10.3390/ijms131217104
10.1007/s00109-011-0825-4
10.1124/mi.6.1.5
10.1242/jcs.064501
10.1007/s11626-016-0070-9
10.1007/s11427-014-4725-z
10.1002/jbmr.7
10.1016/0047-6374(94)91595-4
10.1038/nature16187
10.1113/expphysiol.2008.043133
10.1038/nm.3651
10.1096/fj.00-0764fje
10.3892/mmr.2016.5417
10.1016/j.cell.2016.02.041
10.1038/416507a
10.1038/srep11100
10.1038/nature05949
10.1159/000104152
10.1038/ncb3207
10.1371/journal.pone.0006588
10.1093/humrep/des019
10.1016/j.stemcr.2016.02.006
10.1096/fj.03-1308fje
10.1074/jbc.M111.323709
10.1073/pnas.1120358109
10.1083/jcb.200802155
10.1016/j.stem.2010.09.015
10.1111/jcmm.12395
10.1182/blood-2011-01-330050
10.1002/stem.1050
10.1016/j.molmed.2016.06.005
10.1111/acel.12182
10.1007/s12192-012-0331-9
10.1038/onc.2011.45
10.1038/ncomms7808
10.1038/nm.3465
10.1186/s13287-015-0187-x
10.1073/pnas.112515399
10.1126/science.1143578
10.1113/jphysiol.2002.036673
10.1038/cddis.2013.117
10.1016/j.cell.2008.11.026
10.1016/j.cell.2016.02.014
10.5483/BMBRep.2013.46.8.164
10.3727/000000003771000138
10.1038/cddis.2013.338
10.1111/acel.12060
10.1016/j.scr.2013.01.002
10.1016/j.stem.2016.03.005
10.1016/j.cmet.2014.04.002
10.1038/nrm3060
10.1089/ars.2009.2804
10.1371/journal.pone.0126537
10.1242/dev.014977
10.1126/science.aaf2693
10.1016/j.stem.2013.01.001
10.1371/journal.pone.0021397
10.1038/nature12631
10.1254/jphs.FP0071664
10.1038/srep09819
10.1161/01.ATV.0000142810.27849.8f
10.3727/0963689109X546562
10.1111/j.1474-9726.2011.00704.x
10.1038/nature10815
10.1155/2016/3507290
10.1016/j.semcdb.2016.02.005
10.1016/j.cub.2014.03.034
10.1016/j.exger.2004.06.004
10.1038/mt.2010.160
10.1016/j.arr.2013.12.002
10.4161/cc.7.21.6965
10.1038/nature11895
10.1101/gad.1600707
10.1089/ars.2014.6000
10.1038/nm1388
10.1159/000362623
10.1038/cr.2016.4
10.1371/journal.pbio.0050201
10.1016/j.celrep.2016.09.010
10.1038/ncb2699
10.1016/j.mad.2005.02.003
10.1002/med.21396
10.1016/j.clinbiochem.2012.06.026
10.1371/journal.pone.0111850
10.1002/stem.2450
10.1111/jcpe.12549
10.1016/j.stem.2014.05.009
10.1113/expphysiol.2007.037275
10.1111/gtc.12126
10.1126/science.1144090
10.1016/j.freeradbiomed.2015.06.037
10.1016/j.bbabio.2015.05.014
10.3109/07853890.2014.912836
10.1002/stem.1709
10.1002/hep.20045
10.1186/2046-2395-3-6
10.1016/j.cmet.2012.11.007
10.1016/j.exger.2005.07.006
10.1016/j.biocel.2007.10.008
10.1002/stem.1142
10.3390/molecules21050604
10.1002/stem.2460
10.1016/j.cmet.2007.08.011
10.1089/scd.2009.0313
10.1038/nature11163
10.15252/embj.201488278
10.1172/JCI64125
10.1152/physiolgenomics.00239.2007
10.1002/ibd.20821
10.1038/ncb3385
10.1371/journal.pone.0076699
10.3727/096368916X694274
10.1038/nrm2241
10.1074/jbc.M200373200
10.5966/sctm.2012-0116
10.1016/j.celrep.2013.01.005
10.1038/nri3495
10.1016/j.devcel.2009.06.016
10.1002/jbmr.460
10.1016/j.bbagen.2009.06.003
10.1016/S0092-8674(04)00208-9
10.1016/j.exger.2013.02.025
10.1242/jcs.133314
10.1002/stem.1671
10.1002/jnr.22054
10.3390/ijms17071082
10.1111/jpi.12164
10.1016/j.cell.2005.11.044
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Issue 9
Keywords signaling pathway
aging
stem cell
oxidative stress
transplantation
Language English
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References Liu, Li, Jiang, Li, Zhou, Song, Liu 2016; 2016
Han, Muller, Perez, Qi, Liang, Xi, Fu, Doyle, Hickey, Cornell 2008; 34
Takacs-Vellai, Vellai, Puoti, Passannante, Wicky, Streit, Kovacs, Muller 2005; 15
Perez, Bokov, Van Remmen, Mele, Ran, Ikeno, Richardson 2009; 1790
Si, Chen, Guo, Chen, Wang, Xu, Kang 2013; 8
Signer, Morrison 2013; 12
Schulz, Zarse, Voigt, Urban, Birringer, Ristow 2007; 6
Brack, Conboy, Roy, Lee, Kuo, Keller, Rando 2007; 317
Ho, Chen, Ma, Tseng, Chen, Lee 2011; 20
Chang, Hsu, Wu 2015; 10
Artandi, Alson, Tietze, Sharpless, Ye, Greenberg, Castrillon, Horner, Weiler, Carrasco 2002; 99
O’Neill 2013; 48
Li, Guo, Zhai, Yin, Zhang, Chen, Wang, Li, Liu, Xia 2014; 9
Paul, Bisht, Darmawan, Chiou, Ha, Wallace, Chon, Hegab, Grogan, Elashoff 2014; 15
Niedernhofer, Robbins 2008; 40
Bhattacharyya, Dudeja, Tobacman 2009; 15
Wege, Chui, Le, Strom, Zern 2003; 12
Yu, Lee, Jung, Hong, Kim, Seo, Shin, Kang 2013; 126
Cai, Yu, Zhang, Zhang, Fang, Liu, Liu, Ding 2014; 39
Juhasz, Erdi, Sass, Neufeld 2007; 21
Mohammadzadeh, Halabian, Gharehbaghian, Amirizadeh, Jahanian-Najafabadi, Roushandeh, Roudkenar 2012; 17
Chambers, Shaw, Gatza, Fisk, Donehower, Goodell 2007; 5
Li, Sun, Pang 2015; 5
Arthur, Ley 2013; 13
Yuan, Zhai, Yan, Zhao, Wang, Zeng, Chen, Nan, He, Li 2012; 90
Kanninen, Pomeshchik, Leinonen, Malm, Koistinaho, Levonen 2015; 88
Martini, De Santis, Braccini, Gulluni, Hirsch 2014; 46
Chhabra, Brayman 2013; 2
Drowley, Okada, Beckman, Vella, Keller, Tobita, Huard 2010; 18
Florian, Nattamai, Dorr, Marka, Uberle, Vas, Eckl, Andra, Schiemann, Oostendorp 2013; 503
Gharibi, Farzadi, Ghuman, Hughes 2014; 32
Oh, Lee, Wagers 2014; 20
Meshorer, Gruenbaum 2008; 181
Pan, Guan, Liu, Li, Wang, Wu, Zhou, Zhang, Ren, Zhang 2016; 26
Das, Bayat-Mokhtari, Tsui, Lotfi, Tsuchida, Felsher, Yeger 2012; 30
An, Liu, Xue, Zhang, Wang, Jin 2016; 43
Bernet, Doles, Hall, Kelly Tanaka, Carter, Olwin 2014; 20
Warr, Binnewies, Flach, Reynaud, Garg, Malhotra, Debnath, Passegue 2013; 494
Min-Wen, Jun-Hao, Shyh-Chang 2016; 52
Gambino, De Michele, Venezia, Migliaccio, Dall’Olio, Bernard, Minardi, Della Fazia, Bartoli, Servillo 2013; 12
Son, Kwon, Son, Cho 2016; 34
Schieber, Chandel 2014; 24
Deng, Zhou, Alvarez, Hong, Wang 2016; 6
Chen, Lazarenko, Shankar, Blackburn, Badger, Ronis 2010; 25
Chiou, Chen, Ke, Ko 2012; 45
Bratic, Larsson 2013; 123
Guo, Chakraborty, Rajan, Wang, Huang 2010; 19
Ilic, Ogilvie 2016; 35
Blagosklonny 2008; 7
Xin, Greco, Myung 2016; 164
Kanfi, Naiman, Amir, Peshti, Zinman, Nahum, Bar-Joseph, Cohen 2012; 483
Lee, Nakada, Yilmaz, Tothova, Joseph, Lim, Gilliland, Morrison 2010; 7
Furukawa, Tada-Oikawa, Kawanishi, Oikawa 2007; 20
Kim, de Vellis 2009; 87
Liu, Ghosh, Yang, Zheng, Liu, Wang, Jin, Zheng, Kennedy, Suh 2012; 16
Sun, Wu, Fu, Liu, Huang 2014; 32
Hammond, Sharpless 2008; 135
Zhao, Xiu, Ashton, Xing, Morita, Jordan, Boyce 2012; 30
Shintaku, Peterson, Talbert, Gu, Ladner, Williams, Mousavi, Wang, Sartorelli, Guttridge 2016; 17
Rohani, Johnson, Arnold, Stolzing 2014; 13
Chandel, Jasper, Ho, Passegue 2016; 18
Tang, Rando 2014; 33
Sohal, Agarwal, Candas, Forster, Lal 1994; 76
Xu, Huang, Lin, Fu, Gao, Shen, Zou, Sun, Qian, Ge 2014; 57
Mostoslavsky, Chua, Lombard, Pang, Fischer, Gellon, Liu, Mostoslavsky, Franco, Murphy 2006; 124
Chen, Yi, Morita, Wang, Cong, Liu, Xiao, Rudolph, Cheng, Ju 2015; 6
Tsai, Dudakov, Takahashi, Shieh, Velardi, Holland, Singer, West, Smith, Young 2013; 15
Hou, Han, Jing, Yang, Zhang, Sun, Hao, Meng, Yu, Liu 2013; 4
Pirinen, Canto, Jo, Morato, Zhang, Menzies, Williams, Mouchiroud, Moullan, Hagberg 2014; 19
Matheu, Maraver, Klatt, Flores, Garcia-Cao, Borras, Flores, Vina, Blasco, Serrano 2007; 448
Yilmaz, Katajisto, Lamming, Gultekin, Bauer-Rowe, Sengupta, Birsoy, Dursun, Yilmaz, Selig 2012; 486
Gutierrez-Uzquiza, Arechederra, Bragado, Aguirre-Ghiso, Porras 2012; 287
Arslan, Lai, Smeets, Akeroyd, Choo, Aguor, Timmers, van Rijen, Doevendans, Pasterkamp 2013; 10
Pervaiz, Taneja, Ghaffari 2009; 11
Sharpless, DePinho 2007; 8
Taniguchi Ishikawa, Gonzalez-Nieto, Ghiaur, Dunn, Ficker, Murali, Madhu, Gutstein, Fishman, Barrio 2012; 109
Tomko, Bansal, Lazo 2006; 6
Gredilla, Sanz, Lopez-Torres, Barja 2001; 15
Feng, Zheng, Song, Xu, Huang, Zhang, Cao, Shen, Zhang, Feng 2016; 52
Brady, Attardi 2010; 123
Brown, Xie, Qiu, Mohrin, Shin, Liu, Zhang, Scadden, Chen 2013; 3
Pollina, Brunet 2011; 30
Suzuki, Murtuza, Beauchamp, Smolenski, Varela-Carver, Fukushima, Coppen, Partridge, Yacoub 2004; 18
MacDonald, Tamai, He 2009; 17
Baldari, Di Rocco, Trivisonno, Samengo, Pani, Toietta 2016; 17
Zhang, Ryu, Wu, Gariani, Wang, Luan, D’Amico, Ropelle, Lutolf, Aebersold 2016; 352
Jang, Wang, Lalli, Guzman, Godshalk, Zhou, Kosik 2016; 165
Tseng, Hou, Chen, Peng, Hsieh, Kuo, Yen 2011; 26
Zhang, Cui, Liu, Lv, Liu, Xie, Yu 2015; 6
Garcia-Prat, Martinez-Vicente, Perdiguero, Ortet, Rodriguez-Ubreva, Rebollo, Ruiz-Bonilla, Gutarra, Ballestar, Serrano 2016; 529
Mandal, Blanpain, Rossi 2011; 12
Rice, Desai, Preston, Wehner, Blough 2007; 92
Ahlqvist, Suomalainen, Hamalainen 2015; 1847
Ito, Hirao, Arai, Takubo, Matsuoka, Miyamoto, Ohmura, Naka, Hosokawa, Ikeda 2006; 12
Doe 2008; 135
de Magalhaes, Chainiaux, de Longueville, Mainfroid, Migeot, Marcq, Remacle, Salmon, Toussaint 2004; 39
Zeng, Xiao, Zheng, Xing, Tipoe, Wang, He, Chen, Liu 2015; 5
Sun, Huang, Zhang 2009; 4
Abe, Takiguchi, Ichimaru, Tsuchiya, Wada 2008; 106
Schwarze, DePrimo, Grabert, Fu, Brooks, Jarrard 2002; 277
Chen, Chiang, Chen, Sung, Lee, Tsai, Chang, Chen, Sun, Leu 2014; 57
Lu, Ji, Jiang, You 2016; 36
Chung, Yu 2013; 6
Ocampo, Reddy, Izpisua Belmonte 2016; 22
Zhang, Wang, Tan 2011; 6
Liu, Liu, Wang, Zhou, Cao, Wang, Duan 2011; 10
Tang, Zhou, Wang, Wang, Ding 2015; 8
Erusalimsky, Skene 2009; 94
Yahata, Takanashi, Muguruma, Ibrahim, Matsuzawa, Uno, Sheng, Onizuka, Ito, Kato 2011; 118
Wagers, Weissman 2004; 116
Fujimaki, Wakabayashi, Takemasa, Asashima, Kuwabara 2015; 30
Kim, Park, Song, Kim, Sung 2013; 4
Perales-Clemente, Folmes, Terzic 2014; 21
Liu, Xiong, Xing, Gao, Wang, He, Ren, Liu, So, Xiao 2017; 26
Wang, Shao, Ma, Chen, Sun, Liu, Zhang, Fu, Liu, Jia 2014; 18
Williamson, Gallagher, Harber, Hollon, Trappe 2003; 547
Bose, Bhuvaneswaran, Udupa 2005; 126
Murakami, Shimizu, Romeo, Yamamoto, Motohashi 2014; 19
Chen, Liu, Chen, Cao, Zhang, Hu, Wang 2014; 13
Soria-Valles, Osorio, Gutierrez-Fernandez, De Los Angeles, Bueno, Menendez, Martin-Subero, Daley, Freije, Lopez-Otin 2015; 17
Zeng, Feirt, Goldstein, Guarrera, Ippagunta, Ekong, Dun, Lu, Qu, Schmidt 2004; 39
Fehrer, Lepperdinger 2005; 40
Liu, Fergusson, Castilho, Liu, Cao, Chen, Malide, Rovira, Schimel, Kuo 2007; 317
Li, Liu, Lin, Wang, Huang, Lin, Chen 2016; 21
Wang, Diao, Shi, Zhu, Gao, Gao, Liu, Wu, Rudolph, Liu 2016; 18
Bucciantini, Giannoni, Chiti, Baroni, Formigli, Zurdo, Taddei, Ramponi, Dobson, Stefani 2002; 416
He, Peterson, Holmuhamedov, Terzic, Caplice, Oberley, Katusic 2004; 24
Dai, Chiao, Marcinek, Szeto, Rabinovitch 2014; 3
Xu, Qian, Xie, Lin, Zou, Fu, Huang, Zhang, Su, Ge 2012; 13
Liu, Han, Chen, Tang 2016; 14
Liu, Liu, Ye, Liu, Huang, Wang, Ji, Liu, Tang, Baltz 2012; 27
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References_xml – volume: 13
  start-page: 2
  issue: 1
  year: 2014
  end-page: 7
  article-title: The aging signature: a hallmark of induced pluripotent stem cells?
  publication-title: Aging Cell
– volume: 25
  start-page: 1117
  issue: 5
  year: 2010
  end-page: 1127
  article-title: A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of wnt/beta-catenin signaling
  publication-title: J Bone Miner Res
– volume: 21
  start-page: 1648
  issue: 11
  year: 2014
  end-page: 1659
  article-title: Metabolic regulation of redox status in stem cells
  publication-title: Antioxid Redox Signal
– volume: 13
  start-page: 679
  issue: 9
  year: 2013
  end-page: 692
  article-title: Mitogen-activated protein kinases in innate immunity
  publication-title: Nat Rev Immunol
– volume: 118
  start-page: 2941
  issue: 11
  year: 2011
  end-page: 2950
  article-title: Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
  publication-title: Blood
– volume: 8
  start-page: 5591
  issue: 5
  year: 2015
  end-page: 5596
  article-title: Sirt6/nf-kappab signaling axis in ginsenoside rg1-delayed hematopoietic stem/progenitor cell senescence
  publication-title: Int J Clin Exp Pathol
– volume: 116
  start-page: 639
  issue: 5
  year: 2004
  end-page: 648
  article-title: Plasticity of adult stem cells
  publication-title: Cell
– volume: 317
  start-page: 807
  issue: 5839
  year: 2007
  end-page: 810
  article-title: Increased wnt signaling during aging alters muscle stem cell fate and increases fibrosis
  publication-title: Science
– volume: 448
  start-page: 375
  issue: 7151
  year: 2007
  end-page: 379
  article-title: Delayed ageing through damage protection by the arf/p53 pathway
  publication-title: Nature
– volume: 416
  start-page: 507
  issue: 6880
  year: 2002
  end-page: 511
  article-title: Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
  publication-title: Nature
– volume: 6
  start-page: 280
  issue: 4
  year: 2007
  end-page: 293
  article-title: Glucose restriction extends caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
  publication-title: Cell Metab
– volume: 87
  start-page: 2183
  issue: 10
  year: 2009
  end-page: 2200
  article-title: Stem cell-based cell therapy in neurological diseases: a review
  publication-title: J Neurosci Res
– volume: 39
  start-page: 466
  issue: 6
  year: 2014
  end-page: 475
  article-title: Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury
  publication-title: Am J Nephrol
– volume: 287
  start-page: 2632
  issue: 4
  year: 2012
  end-page: 2642
  article-title: P38alpha mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70s6 k pathway
  publication-title: J Biol Chem
– volume: 9
  start-page: e111850
  issue: 11
  year: 2014
  article-title: Aging increases the susceptivity of mscs to reactive oxygen species and impairs their therapeutic potency for myocardial infarction
  publication-title: PLoS One
– volume: 124
  start-page: 315
  issue: 2
  year: 2006
  end-page: 329
  article-title: Genomic instability and aging-like phenotype in the absence of mammalian Sirt6
  publication-title: Cell
– volume: 1790
  start-page: 1005
  issue: 10
  year: 2009
  end-page: 1014
  article-title: Is the oxidative stress theory of aging dead?
  publication-title: Biochim Biophys Acta
– volume: 52
  start-page: 1001
  issue: 10
  year: 2016
  end-page: 1011
  article-title: SIRT1 was involved in tnf-alpha-promoted osteogenic differentiation of human dpscs through wnt/beta-catenin signal
  publication-title: In Vitro Cell Dev Biol Anim
– volume: 17
  start-page: 553
  issue: 5
  year: 2012
  end-page: 565
  article-title: Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity
  publication-title: Cell Stress Chaperones
– volume: 126
  start-page: 740
  issue: 6–7
  year: 2005
  end-page: 751
  article-title: Age-related alteration in hepatic acyl-coa: cholesterol acyltransferase and its relation to ldl receptor and mapk
  publication-title: Mech Ageing Dev
– volume: 4
  start-page: e588
  year: 2013
  article-title: Reactive oxygen species-responsive mir-210 regulates proliferation and migration of adipose-derived stem cells via ptpn2
  publication-title: Cell Death Dis
– volume: 76
  start-page: 215
  issue: 2–3
  year: 1994
  end-page: 224
  article-title: Effect of age and caloric restriction on DNA oxidative damage in different tissues of c57bl/6 mice
  publication-title: Mech Ageing Dev
– volume: 40
  start-page: 176
  issue: 2
  year: 2008
  end-page: 180
  article-title: Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan
  publication-title: Int J Biochem Cell Biol
– volume: 18
  start-page: 1153
  issue: 10
  year: 2004
  end-page: 1155
  article-title: Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart
  publication-title: FASEB J
– volume: 24
  start-page: 2021
  issue: 11
  year: 2004
  end-page: 2027
  article-title: Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 6
  start-page: 23
  issue: 1
  year: 2006
  end-page: 25
  article-title: Airing out an antioxidant role for the tumor suppressor p53
  publication-title: Mol Interv
– volume: 277
  start-page: 14877
  issue: 17
  year: 2002
  end-page: 14883
  article-title: Novel pathways associated with bypassing cellular senescence in human prostate epithelial cells
  publication-title: J Biol Chem
– volume: 2
  start-page: 328
  issue: 5
  year: 2013
  end-page: 336
  article-title: Stem cell therapy to cure type 1 diabetes: from hype to hope
  publication-title: Stem Cells Transl Med
– volume: 1847
  start-page: 1380
  issue: 11
  year: 2015
  end-page: 1386
  article-title: Stem cells, mitochondria and aging
  publication-title: Biochim Biophys Acta
– volume: 503
  start-page: 392
  issue: 7476
  year: 2013
  end-page: 396
  article-title: A canonical to non-canonical wnt signalling switch in haematopoietic stem-cell ageing
  publication-title: Nature
– volume: 34
  start-page: 112
  issue: 1
  year: 2008
  end-page: 126
  article-title: The in vivo gene expression signature of oxidative stress
  publication-title: Physiol Genomics
– volume: 529
  start-page: 37
  issue: 7584
  year: 2016
  end-page: 42
  article-title: Autophagy maintains stemness by preventing senescence
  publication-title: Nature
– volume: 26
  start-page: 190
  issue: 2
  year: 2016
  end-page: 205
  article-title: Sirt6 safeguards human mesenchymal stem cells from oxidative stress by coactivating nrf2
  publication-title: Cell Res
– volume: 7
  start-page: 593
  issue: 5
  year: 2010
  end-page: 605
  article-title: Mtor activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after pten deletion
  publication-title: Cell Stem Cell
– volume: 547
  start-page: 977
  issue: Pt 3
  year: 2003
  end-page: 987
  article-title: Mitogen-activated protein kinase (mapk) pathway activation: effects of age and acute exercise on human skeletal muscle
  publication-title: J Physiol
– volume: 4
  start-page: e6588
  issue: 8
  year: 2009
  article-title: Phosphorylation of Nrf2 at multiple sites by map kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
  publication-title: PLoS One
– volume: 6
  start-page: 456
  issue: 4
  year: 2016
  end-page: 465
  article-title: Inhibition of ikk/nf-kappab signaling enhances differentiation of mesenchymal stromal cells from human embryonic stem cells
  publication-title: Stem Cell Rep
– volume: 26
  start-page: 2552
  issue: 10
  year: 2011
  end-page: 2563
  article-title: Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating runx2 gene expression via the sirt1/foxo3a axis
  publication-title: J Bone Miner Res
– volume: 39
  start-page: 1379
  issue: 9
  year: 2004
  end-page: 1389
  article-title: Gene expression and regulation in h2o2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase
  publication-title: Exp Gerontol
– volume: 17
  start-page: 9
  issue: 1
  year: 2009
  end-page: 26
  article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases
  publication-title: Dev Cell
– volume: 4
  start-page: e844
  year: 2013
  article-title: Autophagy prevents irradiation injury and maintains stemness through decreasing ros generation in mesenchymal stem cells
  publication-title: Cell Death Dis
– volume: 19
  start-page: 239
  issue: 3
  year: 2014
  end-page: 253
  article-title: Keap1-nrf2 system regulates cell fate determination of hematopoietic stem cells
  publication-title: Genes Cells
– volume: 30
  start-page: 3105
  issue: 28
  year: 2011
  end-page: 3126
  article-title: Epigenetic regulation of aging stem cells
  publication-title: Oncogene
– volume: 135
  start-page: 1575
  issue: 9
  year: 2008
  end-page: 1587
  article-title: Neural stem cells: balancing self-renewal with differentiation
  publication-title: Development
– volume: 36
  start-page: 924
  issue: 5
  year: 2016
  end-page: 963
  article-title: The keap1-nrf2-are pathway as a potential preventive and therapeutic target: an update
  publication-title: Med Res Rev
– volume: 18
  start-page: 495
  issue: 4
  year: 2016
  end-page: 507
  article-title: Sirt6 controls hematopoietic stem cell homeostasis through epigenetic regulation of wnt signaling
  publication-title: Cell Stem Cell
– volume: 109
  start-page: 9071
  issue: 23
  year: 2012
  end-page: 9076
  article-title: Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
  publication-title: Proc Natl Acad Sci USA
– volume: 48
  start-page: 647
  issue: 7
  year: 2013
  end-page: 653
  article-title: Pi3-kinase/akt/mtor signaling: impaired on/off switches in aging, cognitive decline and alzheimer’s disease
  publication-title: Exp Gerontol
– volume: 43
  start-page: 618
  issue: 7
  year: 2016
  end-page: 625
  article-title: Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment
  publication-title: J Clin Periodontol
– volume: 33
  start-page: 2782
  issue: 23
  year: 2014
  end-page: 2797
  article-title: Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation
  publication-title: EMBO J
– volume: 17
  issue: 7
  year: 2016
  article-title: Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase
  publication-title: Int J Mol Sci
– volume: 486
  start-page: 490
  issue: 7404
  year: 2012
  end-page: 495
  article-title: Mtorc1 in the paneth cell niche couples intestinal stem-cell function to calorie intake
  publication-title: Nature
– volume: 15
  start-page: 1513
  issue: 16
  year: 2005
  end-page: 1517
  article-title: Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in c. Elegans
  publication-title: Curr Biol
– volume: 8
  start-page: 703
  issue: 9
  year: 2007
  end-page: 713
  article-title: How stem cells age and why this makes us grow old
  publication-title: Nat Rev Mol Cell Biol
– volume: 21
  issue: 5
  year: 2016
  article-title: Protective effects of dihydromyricetin against *oh-induced mesenchymal stem cells damage and mechanistic chemistry
  publication-title: Molecules
– volume: 94
  start-page: 299
  issue: 3
  year: 2009
  end-page: 304
  article-title: Mechanisms of endothelial senescence
  publication-title: Exp Physiol
– volume: 40
  start-page: 926
  issue: 12
  year: 2005
  end-page: 930
  article-title: Mesenchymal stem cell aging
  publication-title: Exp Gerontol
– volume: 20
  start-page: 1209
  issue: 8
  year: 2011
  end-page: 1220
  article-title: Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of ras and oxidative stress
  publication-title: Cell Transplant
– volume: 32
  start-page: 2256
  issue: 8
  year: 2014
  end-page: 2266
  article-title: Inhibition of akt/mtor attenuates age-related changes in mesenchymal stem cells
  publication-title: Stem Cells
– volume: 6
  start-page: 195
  year: 2015
  article-title: Roles of microrna-34a targeting sirt1 in mesenchymal stem cells
  publication-title: Stem Cell Res Ther
– volume: 494
  start-page: 323
  issue: 7437
  year: 2013
  end-page: 327
  article-title: Foxo3a directs a protective autophagy program in haematopoietic stem cells
  publication-title: Nature
– volume: 123
  start-page: 951
  issue: 3
  year: 2013
  end-page: 957
  article-title: The role of mitochondria in aging
  publication-title: J Clin Invest
– volume: 24
  start-page: R453
  issue: 10
  year: 2014
  end-page: R462
  article-title: ROS function in redox signaling and oxidative stress
  publication-title: Curr Biol
– volume: 18
  start-page: 823
  issue: 8
  year: 2016
  end-page: 832
  article-title: Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
  publication-title: Nat Cell Biol
– volume: 57
  start-page: 989
  issue: 10
  year: 2014
  end-page: 997
  article-title: Mir-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation
  publication-title: Sci China Life Sci
– volume: 6
  start-page: e21397
  issue: 6
  year: 2011
  article-title: Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
  publication-title: PLoS One
– volume: 123
  start-page: 2527
  issue: Pt 15
  year: 2010
  end-page: 2532
  article-title: P53 at a glance
  publication-title: J Cell Sci
– volume: 7
  start-page: 3344
  issue: 21
  year: 2008
  end-page: 3354
  article-title: Aging: ros or tor
  publication-title: Cell Cycle
– volume: 17
  start-page: 514
  issue: 2
  year: 2016
  end-page: 526
  article-title: Myod regulates skeletal muscle oxidative metabolism cooperatively with alternative nf-kappab
  publication-title: Cell Rep
– volume: 10
  start-page: 301
  issue: 3
  year: 2013
  end-page: 312
  article-title: Mesenchymal stem cell-derived exosomes increase atp levels, decrease oxidative stress and activate pi3k/akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
  publication-title: Stem Cell Res
– volume: 181
  start-page: 9
  issue: 1
  year: 2008
  end-page: 13
  article-title: Gone with the wnt/notch: stem cells in laminopathies, progeria, and aging
  publication-title: J Cell Biol
– volume: 15
  start-page: 309
  issue: 3
  year: 2013
  end-page: 316
  article-title: Nrf2 regulates haematopoietic stem cell function
  publication-title: Nat Cell Biol
– volume: 18
  start-page: 2298
  issue: 11
  year: 2014
  end-page: 2310
  article-title: Decreased sirt3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress
  publication-title: J Cell Mol Med
– volume: 90
  start-page: 389
  issue: 4
  year: 2012
  end-page: 400
  article-title: SIRT1 is required for long-term growth of human mesenchymal stem cells
  publication-title: J Mol Med
– volume: 5
  start-page: e201
  issue: 8
  year: 2007
  article-title: Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
  publication-title: PLoS Biol
– volume: 32
  start-page: 1943
  issue: 7
  year: 2014
  end-page: 1955
  article-title: Sirt6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-kappab signaling pathway
  publication-title: Stem Cells
– volume: 10
  start-page: e0126537
  issue: 5
  year: 2015
  article-title: High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy
  publication-title: PLoS One
– volume: 5
  start-page: 11100
  year: 2015
  article-title: Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model
  publication-title: Sci Rep
– volume: 483
  start-page: 218
  issue: 7388
  year: 2012
  end-page: 221
  article-title: The sirtuin sirt6 regulates lifespan in male mice
  publication-title: Nature
– volume: 15
  start-page: 199
  issue: 2
  year: 2014
  end-page: 214
  article-title: Dynamic changes in intracellular ros levels regulate airway basal stem cell homeostasis through nrf2-dependent notch signaling
  publication-title: Cell Stem Cell
– volume: 15
  start-page: 1589
  issue: 9
  year: 2001
  end-page: 1591
  article-title: Caloric restriction decreases mitochondrial free radical generation at complex i and lowers oxidative damage to mitochondrial DNA in the rat heart
  publication-title: FASEB J
– volume: 30
  start-page: 709
  issue: 4
  year: 2012
  end-page: 718
  article-title: Noncanonical nf-kappab signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions
  publication-title: Stem Cells
– volume: 11
  start-page: 2777
  issue: 11
  year: 2009
  end-page: 2789
  article-title: Oxidative stress regulation of stem and progenitor cells
  publication-title: Antioxid Redox Signal
– volume: 20
  start-page: 45
  issue: 1–4
  year: 2007
  end-page: 54
  article-title: H2o2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of sirt1 by nad+ depletion
  publication-title: Cell Physiol Biochem
– volume: 20
  start-page: 265
  issue: 3
  year: 2014
  end-page: 271
  article-title: P38 mapk signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
  publication-title: Nat Med
– volume: 27
  start-page: 1411
  issue: 5
  year: 2012
  end-page: 1420
  article-title: Delay in oocyte aging in mice by the antioxidant n-acetyl-l-cysteine (nac)
  publication-title: Hum Reprod
– volume: 126
  start-page: 5422
  issue: Pt 23
  year: 2013
  end-page: 5431
  article-title: Microrna-141-3p plays a role in human mesenchymal stem cell aging by directly targeting zmpste24
  publication-title: J Cell Sci
– volume: 45
  start-page: 1389
  issue: 16–17
  year: 2012
  end-page: 1393
  article-title: The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis c patients
  publication-title: Clin Biochem
– volume: 12
  start-page: 897
  issue: 8
  year: 2003
  end-page: 906
  article-title: In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
  publication-title: Cell Transplant
– volume: 26
  start-page: 805
  issue: 5
  year: 2017
  end-page: 820
  article-title: Precise regulation of miR-210 is critical for the cellular homeostasis maintenance and transplantation efficacy enhancement of mesenchymal stem cell in acute liver failure therapy
  publication-title: Cell Transplant
– volume: 14
  start-page: 1643
  issue: 2
  year: 2016
  end-page: 1648
  article-title: Mechanism of osteogenic and adipogenic differentiation of tendon stem cells induced by sirtuin 1
  publication-title: Mol Med Rep
– volume: 57
  start-page: 248
  issue: 3
  year: 2014
  end-page: 261
  article-title: Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat
  publication-title: J Pineal Res
– volume: 99
  start-page: 8191
  issue: 12
  year: 2002
  end-page: 8196
  article-title: Constitutive telomerase expression promotes mammary carcinomas in aging mice
  publication-title: Proc Natl Acad Sci USA
– volume: 12
  start-page: 435
  issue: 3
  year: 2013
  end-page: 445
  article-title: Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
  publication-title: Aging Cell
– volume: 8
  start-page: e76699
  issue: 10
  year: 2013
  article-title: Activation of GSK3beta by Sirt2 is required for early lineage commitment of mouse embryonic stem cell
  publication-title: PLoS One
– volume: 88
  start-page: 350
  issue: Pt B
  year: 2015
  end-page: 361
  article-title: Applications of the keap1-nrf2 system for gene and cell therapy
  publication-title: Free Radic Biol Med
– volume: 30
  start-page: 1411
  issue: 12
  year: 2015
  end-page: 1430
  article-title: The regulation of stem cell aging by wnt signaling
  publication-title: Histol Histopathol
– volume: 30
  start-page: 1685
  issue: 8
  year: 2012
  end-page: 1695
  article-title: HIF-2alpha suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells
  publication-title: Stem Cells
– volume: 13
  start-page: 17104
  issue: 12
  year: 2012
  end-page: 17120
  article-title: High density lipoprotein protects mesenchymal stem cells from oxidative stress-induced apoptosis via activation of the pi3k/akt pathway and suppression of reactive oxygen species
  publication-title: Int J Mol Sci
– volume: 34
  start-page: 2840
  issue: 12
  year: 2016
  end-page: 2851
  article-title: Restoration of mitochondrial nad+ levels delays stem cell senescence and facilitates reprogramming of aged somatic cells
  publication-title: Stem Cells
– volume: 46
  start-page: 372
  issue: 6
  year: 2014
  end-page: 383
  article-title: Pi3k/akt signaling pathway and cancer: an updated review
  publication-title: Ann Med
– volume: 10
  start-page: 661
  issue: 4
  year: 2011
  end-page: 674
  article-title: The pi3k-akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro
  publication-title: Aging Cell
– volume: 6
  start-page: 6808
  year: 2015
  article-title: Wip1 deficiency impairs haematopoietic stem cell function via p53 and mtorc1 pathways
  publication-title: Nat Commun
– volume: 15
  start-page: 673
  issue: 5
  year: 2009
  end-page: 683
  article-title: ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of ikappaBa, NFkappaB, and IL-8
  publication-title: Inflamm Bowel Dis
– volume: 92
  start-page: 963
  issue: 5
  year: 2007
  end-page: 970
  article-title: Uniaxial stretch-induced regulation of mitogen-activated protein kinase, Akt and p70 S6 kinase in the ageing fischer 344 x Brown Norway rat aorta
  publication-title: Exp Physiol
– volume: 352
  start-page: 1436
  issue: 6292
  year: 2016
  end-page: 1443
  article-title: Nad(+) repletion improves mitochondrial and stem cell function and enhances life span in mice
  publication-title: Science
– volume: 3
  start-page: 319
  issue: 2
  year: 2013
  end-page: 327
  article-title: Sirt3 reverses aging-associated degeneration
  publication-title: Cell Rep
– volume: 21
  start-page: 3061
  issue: 23
  year: 2007
  end-page: 3066
  article-title: Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in drosophila
  publication-title: Genes Dev
– volume: 3
  start-page: 6
  year: 2014
  article-title: Mitochondrial oxidative stress in aging and healthspan
  publication-title: Longev Healthspan
– volume: 12
  start-page: 152
  issue: 2
  year: 2013
  end-page: 165
  article-title: Mechanisms that regulate stem cell aging and life span
  publication-title: Cell Stem Cell
– volume: 52
  start-page: 110
  year: 2016
  end-page: 118
  article-title: Stem cell mitochondria during aging
  publication-title: Semin Cell Dev Biol
– volume: 19
  start-page: 1034
  issue: 6
  year: 2014
  end-page: 1041
  article-title: Pharmacological inhibition of poly(adp-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle
  publication-title: Cell Metab
– volume: 2016
  start-page: 3507290
  year: 2016
  article-title: Inhibition of hsp90 promotes neural stem cell survival from oxidative stress through attenuating nf-kappab/p65 activation
  publication-title: Oxid Med Cell Longev
– volume: 39
  start-page: 422
  issue: 2
  year: 2004
  end-page: 432
  article-title: Blockade of receptor for advanced glycation end product (rage) attenuates ischemia and reperfusion injury to the liver in mice
  publication-title: Hepatology
– volume: 164
  start-page: 1212
  issue: 6
  year: 2016
  end-page: 1225
  article-title: Hardwiring stem cell communication through tissue structure
  publication-title: Cell
– volume: 13
  start-page: 55
  year: 2014
  end-page: 64
  article-title: Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
  publication-title: Ageing Res Rev
– volume: 16
  start-page: 738
  issue: 6
  year: 2012
  end-page: 750
  article-title: Resveratrol rescues sirt1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
  publication-title: Cell Metab
– volume: 135
  start-page: 1013
  issue: 6
  year: 2008
  end-page: 1016
  article-title: Hmga2, micrornas, and stem cell aging
  publication-title: Cell
– volume: 19
  start-page: 1321
  issue: 9
  year: 2010
  end-page: 1331
  article-title: Effects of oxidative stress on mouse embryonic stem cell proliferation, apoptosis, senescence, and self-renewal
  publication-title: Stem Cells Dev
– volume: 5
  start-page: 9819
  year: 2015
  article-title: Synergistic protection of -acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis
  publication-title: Sci Rep
– volume: 35
  start-page: 17
  issue: 1
  year: 2016
  end-page: 25
  article-title: Human embryonic stem cells-what have we done? What are we doing? Where are we going?
  publication-title: Stem Cells
– volume: 18
  start-page: 1865
  issue: 10
  year: 2010
  end-page: 1873
  article-title: Cellular antioxidant levels influence muscle stem cell therapy
  publication-title: Mol Ther
– volume: 6
  start-page: 383
  issue: 8
  year: 2013
  end-page: 390
  article-title: Interplay between autophagy and programmed cell death in mammalian neural stem cells
  publication-title: BMB Rep
– volume: 20
  start-page: 870
  issue: 8
  year: 2014
  end-page: 880
  article-title: Stem cell aging: mechanisms, regulators and therapeutic opportunities
  publication-title: Nat Med
– volume: 22
  start-page: 725
  issue: 8
  year: 2016
  end-page: 738
  article-title: Anti-aging strategies based on cellular reprogramming
  publication-title: Trends Mol Med
– volume: 165
  start-page: 410
  issue: 2
  year: 2016
  end-page: 420
  article-title: Primary cilium-autophagy-nrf2 (pan) axis activation commits human embryonic stem cells to a neuroectoderm fate
  publication-title: Cell
– volume: 17
  start-page: 1004
  issue: 8
  year: 2015
  end-page: 1013
  article-title: Nf-kappab activation impairs somatic cell reprogramming in ageing
  publication-title: Nat Cell Biol
– volume: 106
  start-page: 571
  issue: 4
  year: 2008
  end-page: 577
  article-title: Comparison of the protective effect of -acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury
  publication-title: J Pharmacol Sci
– volume: 12
  start-page: 198
  issue: 3
  year: 2011
  end-page: 202
  article-title: DNA damage response in adult stem cells: pathways and consequences
  publication-title: Nat Rev Mol Cell Biol
– volume: 317
  start-page: 803
  issue: 5839
  year: 2007
  end-page: 806
  article-title: Augmented wnt signaling in a mammalian model of accelerated aging
  publication-title: Science
– volume: 12
  start-page: 446
  issue: 4
  year: 2006
  end-page: 451
  article-title: Reactive oxygen species act through p38 mapk to limit the lifespan of hematopoietic stem cells
  publication-title: Nat Med
– ident: bibr97-0963689717735407
  doi: 10.1016/j.cub.2005.07.035
– ident: bibr62-0963689717735407
  doi: 10.3390/ijms131217104
– ident: bibr80-0963689717735407
  doi: 10.1007/s00109-011-0825-4
– ident: bibr50-0963689717735407
  doi: 10.1124/mi.6.1.5
– ident: bibr47-0963689717735407
  doi: 10.1242/jcs.064501
– ident: bibr83-0963689717735407
  doi: 10.1007/s11626-016-0070-9
– ident: bibr21-0963689717735407
  doi: 10.1007/s11427-014-4725-z
– ident: bibr45-0963689717735407
  doi: 10.1002/jbmr.7
– ident: bibr16-0963689717735407
  doi: 10.1016/0047-6374(94)91595-4
– ident: bibr102-0963689717735407
  doi: 10.1038/nature16187
– ident: bibr8-0963689717735407
  doi: 10.1113/expphysiol.2008.043133
– ident: bibr14-0963689717735407
  doi: 10.1038/nm.3651
– ident: bibr17-0963689717735407
  doi: 10.1096/fj.00-0764fje
– ident: bibr82-0963689717735407
  doi: 10.3892/mmr.2016.5417
– ident: bibr2-0963689717735407
  doi: 10.1016/j.cell.2016.02.041
– ident: bibr25-0963689717735407
  doi: 10.1038/416507a
– ident: bibr36-0963689717735407
  doi: 10.1038/srep11100
– ident: bibr54-0963689717735407
  doi: 10.1038/nature05949
– ident: bibr49-0963689717735407
  doi: 10.1159/000104152
– ident: bibr65-0963689717735407
  doi: 10.1038/ncb3207
– ident: bibr77-0963689717735407
  doi: 10.1371/journal.pone.0006588
– ident: bibr94-0963689717735407
  doi: 10.1093/humrep/des019
– ident: bibr69-0963689717735407
  doi: 10.1016/j.stemcr.2016.02.006
– ident: bibr117-0963689717735407
  doi: 10.1096/fj.03-1308fje
– ident: bibr78-0963689717735407
  doi: 10.1074/jbc.M111.323709
– ident: bibr55-0963689717735407
  doi: 10.1073/pnas.1120358109
– ident: bibr42-0963689717735407
  doi: 10.1083/jcb.200802155
– ident: bibr51-0963689717735407
  doi: 10.1016/j.stem.2010.09.015
– ident: bibr86-0963689717735407
  doi: 10.1111/jcmm.12395
– ident: bibr115-0963689717735407
  doi: 10.1182/blood-2011-01-330050
– ident: bibr126-0963689717735407
  doi: 10.1002/stem.1050
– ident: bibr4-0963689717735407
  doi: 10.1016/j.molmed.2016.06.005
– ident: bibr7-0963689717735407
  doi: 10.1111/acel.12182
– ident: bibr31-0963689717735407
  doi: 10.1007/s12192-012-0331-9
– ident: bibr24-0963689717735407
  doi: 10.1038/onc.2011.45
– ident: bibr52-0963689717735407
  doi: 10.1038/ncomms7808
– ident: bibr76-0963689717735407
  doi: 10.1038/nm.3465
– ident: bibr81-0963689717735407
  doi: 10.1186/s13287-015-0187-x
– ident: bibr129-0963689717735407
  doi: 10.1073/pnas.112515399
– ident: bibr40-0963689717735407
  doi: 10.1126/science.1143578
– ident: bibr72-0963689717735407
  doi: 10.1113/jphysiol.2002.036673
– ident: bibr108-0963689717735407
  doi: 10.1038/cddis.2013.117
– volume: 30
  start-page: 1411
  issue: 12
  year: 2015
  ident: bibr39-0963689717735407
  publication-title: Histol Histopathol
– ident: bibr111-0963689717735407
  doi: 10.1016/j.cell.2008.11.026
– ident: bibr35-0963689717735407
  doi: 10.1016/j.cell.2016.02.014
– ident: bibr103-0963689717735407
  doi: 10.5483/BMBRep.2013.46.8.164
– ident: bibr5-0963689717735407
  doi: 10.3727/000000003771000138
– ident: bibr105-0963689717735407
  doi: 10.1038/cddis.2013.338
– ident: bibr48-0963689717735407
  doi: 10.1111/acel.12060
– ident: bibr61-0963689717735407
  doi: 10.1016/j.scr.2013.01.002
– ident: bibr91-0963689717735407
  doi: 10.1016/j.stem.2016.03.005
– ident: bibr19-0963689717735407
  doi: 10.1016/j.cmet.2014.04.002
– ident: bibr26-0963689717735407
  doi: 10.1038/nrm3060
– ident: bibr15-0963689717735407
  doi: 10.1089/ars.2009.2804
– ident: bibr107-0963689717735407
  doi: 10.1371/journal.pone.0126537
– ident: bibr11-0963689717735407
  doi: 10.1242/dev.014977
– ident: bibr20-0963689717735407
  doi: 10.1126/science.aaf2693
– ident: bibr12-0963689717735407
  doi: 10.1016/j.stem.2013.01.001
– ident: bibr43-0963689717735407
  doi: 10.1371/journal.pone.0021397
– ident: bibr44-0963689717735407
  doi: 10.1038/nature12631
– ident: bibr23-0963689717735407
  doi: 10.1254/jphs.FP0071664
– ident: bibr106-0963689717735407
  doi: 10.1038/srep09819
– ident: bibr118-0963689717735407
  doi: 10.1161/01.ATV.0000142810.27849.8f
– ident: bibr13-0963689717735407
  doi: 10.3727/0963689109X546562
– ident: bibr60-0963689717735407
  doi: 10.1111/j.1474-9726.2011.00704.x
– ident: bibr89-0963689717735407
  doi: 10.1038/nature10815
– ident: bibr67-0963689717735407
  doi: 10.1155/2016/3507290
– ident: bibr29-0963689717735407
  doi: 10.1016/j.semcdb.2016.02.005
– ident: bibr22-0963689717735407
  doi: 10.1016/j.cub.2014.03.034
– ident: bibr10-0963689717735407
  doi: 10.1016/j.exger.2004.06.004
– ident: bibr37-0963689717735407
  doi: 10.1038/mt.2010.160
– ident: bibr79-0963689717735407
  doi: 10.1016/j.arr.2013.12.002
– ident: bibr58-0963689717735407
  doi: 10.4161/cc.7.21.6965
– ident: bibr99-0963689717735407
  doi: 10.1038/nature11895
– ident: bibr98-0963689717735407
  doi: 10.1101/gad.1600707
– ident: bibr113-0963689717735407
  doi: 10.1089/ars.2014.6000
– ident: bibr75-0963689717735407
  doi: 10.1038/nm1388
– ident: bibr122-0963689717735407
  doi: 10.1159/000362623
– ident: bibr90-0963689717735407
  doi: 10.1038/cr.2016.4
– ident: bibr53-0963689717735407
  doi: 10.1371/journal.pbio.0050201
– ident: bibr68-0963689717735407
  doi: 10.1016/j.celrep.2016.09.010
– ident: bibr32-0963689717735407
  doi: 10.1038/ncb2699
– ident: bibr71-0963689717735407
  doi: 10.1016/j.mad.2005.02.003
– ident: bibr30-0963689717735407
  doi: 10.1002/med.21396
– ident: bibr116-0963689717735407
  doi: 10.1016/j.clinbiochem.2012.06.026
– ident: bibr120-0963689717735407
  doi: 10.1371/journal.pone.0111850
– ident: bibr1-0963689717735407
  doi: 10.1002/stem.2450
– ident: bibr104-0963689717735407
  doi: 10.1111/jcpe.12549
– ident: bibr34-0963689717735407
  doi: 10.1016/j.stem.2014.05.009
– ident: bibr73-0963689717735407
  doi: 10.1113/expphysiol.2007.037275
– ident: bibr33-0963689717735407
  doi: 10.1111/gtc.12126
– ident: bibr41-0963689717735407
  doi: 10.1126/science.1144090
– ident: bibr125-0963689717735407
  doi: 10.1016/j.freeradbiomed.2015.06.037
– ident: bibr28-0963689717735407
  doi: 10.1016/j.bbabio.2015.05.014
– ident: bibr57-0963689717735407
  doi: 10.3109/07853890.2014.912836
– ident: bibr63-0963689717735407
  doi: 10.1002/stem.1709
– ident: bibr74-0963689717735407
  doi: 10.1002/hep.20045
– ident: bibr131-0963689717735407
  doi: 10.1186/2046-2395-3-6
– ident: bibr95-0963689717735407
  doi: 10.1016/j.cmet.2012.11.007
– ident: bibr6-0963689717735407
  doi: 10.1016/j.exger.2005.07.006
– ident: bibr66-0963689717735407
  doi: 10.1016/j.biocel.2007.10.008
– ident: bibr56-0963689717735407
  doi: 10.1002/stem.1142
– ident: bibr124-0963689717735407
  doi: 10.3390/molecules21050604
– ident: bibr87-0963689717735407
  doi: 10.1002/stem.2460
– ident: bibr18-0963689717735407
  doi: 10.1016/j.cmet.2007.08.011
– ident: bibr112-0963689717735407
  doi: 10.1089/scd.2009.0313
– ident: bibr100-0963689717735407
  doi: 10.1038/nature11163
– ident: bibr101-0963689717735407
  doi: 10.15252/embj.201488278
– ident: bibr27-0963689717735407
  doi: 10.1172/JCI64125
– ident: bibr46-0963689717735407
  doi: 10.1152/physiolgenomics.00239.2007
– ident: bibr64-0963689717735407
  doi: 10.1002/ibd.20821
– ident: bibr119-0963689717735407
  doi: 10.1038/ncb3385
– ident: bibr84-0963689717735407
  doi: 10.1371/journal.pone.0076699
– ident: bibr109-0963689717735407
  doi: 10.3727/096368916X694274
– ident: bibr114-0963689717735407
  doi: 10.1038/nrm2241
– ident: bibr9-0963689717735407
  doi: 10.1074/jbc.M200373200
– ident: bibr128-0963689717735407
  doi: 10.5966/sctm.2012-0116
– ident: bibr85-0963689717735407
  doi: 10.1016/j.celrep.2013.01.005
– ident: bibr70-0963689717735407
  doi: 10.1038/nri3495
– ident: bibr38-0963689717735407
  doi: 10.1016/j.devcel.2009.06.016
– ident: bibr96-0963689717735407
  doi: 10.1002/jbmr.460
– ident: bibr130-0963689717735407
  doi: 10.1016/j.bbagen.2009.06.003
– ident: bibr3-0963689717735407
  doi: 10.1016/S0092-8674(04)00208-9
– ident: bibr59-0963689717735407
  doi: 10.1016/j.exger.2013.02.025
– ident: bibr110-0963689717735407
  doi: 10.1242/jcs.133314
– ident: bibr92-0963689717735407
  doi: 10.1002/stem.1671
– ident: bibr127-0963689717735407
  doi: 10.1002/jnr.22054
– ident: bibr123-0963689717735407
  doi: 10.3390/ijms17071082
– volume: 8
  start-page: 5591
  issue: 5
  year: 2015
  ident: bibr93-0963689717735407
  publication-title: Int J Clin Exp Pathol
– ident: bibr121-0963689717735407
  doi: 10.1111/jpi.12164
– ident: bibr88-0963689717735407
  doi: 10.1016/j.cell.2005.11.044
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Snippet Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and...
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SubjectTerms Aging
Antioxidants
Apoptosis
Carbohydrates
Homeostasis
Lipids
Macromolecules
Original
Oxidative stress
Reactive oxygen species
Senescence
Stem cells
Transplantation
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Title Oxidative Stress in Stem Cell Aging
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Volume 26
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