When myasthenia gravis is deemed refractory: clinical signposts and treatment strategies

• Published in: Therapeutic advances in neurological disorders Vol. 11; p. 1756285617749134
• Main Authors: Mantegazza, Renato, Antozzi, Carlo
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2018; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Monoclonal antibodies; Myasthenia gravis; Pathophysiology; Review; myasthenia gravis; treatment refractory; treatment intolerant; muscle-specific tyrosine kinase antibodies; acetylcholine receptor antibodies; monoclonal antibodies

The prognosis for patients with myasthenia gravis (MG) has improved significantly over the past half century, including substantial reductions in mortality and morbidity. However, approximately 10% of patients fails to respond adequately to current therapies and are considered treatment refractory,...