Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

• Published in: Molecular imaging Vol. 17; p. 1536012118792317
• Main Authors: Narayanaswami, Vidya, Dahl, Kenneth, Bernard-Gauthier, Vadim, Josephson, Lee, Cumming, Paul, Vasdev, Neil
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2018; Sage Publications Ltd; SAGE Publishing
• Subjects: Activation; Advanced glycosylation end products; Amine oxidase (flavin-containing); Animals; Arachidonic acid; Astrocytes; Binding sites; Biomarkers; Brain - diagnostic imaging; Brain - pathology; Cannabinoids; Central nervous system; Chemokines; CX3CR1 protein; Cytokines; Emission analysis; Glia; Glycogen; Glycogen synthase kinase 3; Glycosylation; Humans; Imidazoline; Immunoglobulin receptors; Inflammation; Inflammation - diagnostic imaging; Inflammatory response; Intracellular signalling; Kinases; Macrophages; Medical imaging; Microglia; Myeloid cells; Nervous system; Neurodegenerative diseases; Neurodegenerative Diseases - diagnostic imaging; Neuroglia; Neuroimaging; Neurological diseases; Phospholipase; Phospholipase A2; Positron emission; Positron emission tomography; Prostaglandin endoperoxide synthase; Proteins; Quantitation; Radioactive tracers; Radiopharmaceuticals - chemistry; Reactive oxygen species; Receptors; Receptors, GABA - metabolism; Review; Selectivity; Target recognition; Tomography; Tyrosine; neurodegenerative diseases; astrocytes; neuroinflammation; microglia; positron emission tomography (PET) imaging
• ISSN: 1536-0121; 1535-3508; 1536-0121
• DOI: 10.1177/1536012118792317

The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the n...