Identification of two novel immunodominant UreB CD4+ T cell epitopes in Helicobacter pylori infected subjects

• Published in: Vaccine Vol. 31; no. 8; pp. 1204 - 1209
• Main Authors: Yang, Wu-Chen, Chen, Li, Li, Hai-Bo, Li, Bin, Hu, Jian, Zhang, Jin-Yong, Yang, Shi-Ming, Zou, Quan-Ming, Guo, Hong, Wu, Chao
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 06.02.2013; Elsevier
• Subjects: alleles; Allergy and Immunology; Antigens, Bacterial - immunology; Applied microbiology; B-lymphocytes; Bacteriology; Biological and medical sciences; CD4-positive T-lymphocytes; CD4-Positive T-Lymphocytes - immunology; Epitope; Epitope Mapping; epitopes; Epitopes, T-Lymphocyte - immunology; Fundamental and applied biological sciences. Psychology; Helicobacter Infections - immunology; Helicobacter pylori; Helicobacter pylori - immunology; HLA; HLA-DRB1 Chains - immunology; Humans; Microbiology; Miscellaneous; peptides; Urease - immunology; UreB; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); ICS; FCM; UreB; Epitope; HLA; human leukocyte antigen; intercellular cytokine staining; flow cytometry; Human; HLA-System; CD4 T lymphocyte; Spirillales; Antigenic determinant; Spirillaceae; Identification; Immunodominance; Helicobacter pylori; Bacteria

► UreB-specific CD4+ T cells from two H. pylori infected subjects were expanded in vitro. ► The UreB373–385 peptide recognized by UreB-specific CD4+ T cells from subject 4529 was restricted to DRB1*1404. ► The UreB438–452 peptide recognized by UreB-specific CD4+ T cells from subject 4493 is restrict...