Pharmacokinetics and safety of two Voriconazole formulations after intravenous infusion in two doses in healthy Chinese subjects

• Published in: BMC pharmacology & toxicology Vol. 24; no. 1; pp. 14 - 7
• Main Authors: Li, Xin, Wang, Chenjing, Shi, Ping, Liu, Yanping, Tao, Ye, Lin, Pingping, Li, Ting, Hu, Haixun, Sun, Feifei, Liu, Shuqin, Fu, Yao, Cao, Yu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.03.2023; BioMed Central; BMC
• Subjects: Antifungal agents; Biochemistry; Bioequivalence; Blood pressure; Body mass index; Body temperature; Chromatography; Chromatography, Liquid; Drug dosages; East Asian People; Electrocardiography; Equivalence; Ethics; Health aspects; Heart rate; Hematology; Hepatitis; Humans; Infection; Infusion pumps; Infusions, Intravenous; Intravenous infusion; Laboratories; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Medical research; Medicine, Experimental; Mycoses; Pharmacokinetics; Pharmacology; Plasma; Safety; Safety and security measures; Tandem Mass Spectrometry; Urinalysis; Variance analysis; Vital signs; Voriconazole; Voriconazole - pharmacokinetics; Women; United States > US; Safety; Bioequivalence; Pharmacokinetics; Voriconazole

Voriconazole is a second-generation triazole that is used to prevent and treat invasive fungal infections. The purpose of this study was to evaluate the pharmacokinetic equivalency of a test formulation and reference formulation (Vfend®) of Voriconazole. This was a randomized, open-label, single-dos...