N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

• Published in: BMC medical genomics Vol. 10; no. S1; pp. 27 - 16
• Main Authors: Li, Qike, Schissler, A. Grant, Gardeux, Vincent, Achour, Ikbel, Kenost, Colleen, Berghout, Joanne, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2017; BioMed Central; BMC
• Subjects: Bioinformatics; Cancer; Competition; Consortia; Data processing; Datasets; Gene expression; Gene Expression Profiling - methods; Genetic regulation; Genetic research; Genomes; Genomics; Head & neck cancer; Head and neck; Head and neck carcinoma; Head and Neck Neoplasms - genetics; Head and neck squamous cell carcinomas (HNSCCs); Health aspects; Humans; Mixture Model; N-of-1-pathways; Neoplasms, Squamous Cell - genetics; Ontology; Patients; Precision Medicine; Properties; Ribonucleic acid; RNA; RNA-Seq; ROC Curve; Single-Subject Analysis; Squamous cell carcinoma; Statistical analysis; Transcription factors; Head and neck squamous cell carcinomas (HNSCCs); Single-Subject Analysis; RNA-Seq; Mixture Model; N-of-1-pathways; Precision Medicine

Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions, these methods are not designed to address single-patient transcriptome analyses. We previ...