A Landscape of Driver Mutations in Melanoma

• Published in: Cell Vol. 150; no. 2; pp. 251 - 263
• Main Authors: Hodis, Eran, Watson, Ian R., Kryukov, Gregory V., Arold, Stefan T., Imielinski, Marcin, Theurillat, Jean-Philippe, Nickerson, Elizabeth, Auclair, Daniel, Li, Liren, Place, Chelsea, DiCara, Daniel, Ramos, Alex H., Lawrence, Michael S., Cibulskis, Kristian, Sivachenko, Andrey, Voet, Douglas, Saksena, Gordon, Stransky, Nicolas, Onofrio, Robert C., Winckler, Wendy, Ardlie, Kristin, Wagle, Nikhil, Wargo, Jennifer, Chong, Kelly, Morton, Donald L., Stemke-Hale, Katherine, Chen, Guo, Noble, Michael, Meyerson, Matthew, Ladbury, John E., Davies, Michael A., Gershenwald, Jeffrey E., Wagner, Stephan N., Hoon, Dave S.B., Schadendorf, Dirk, Lander, Eric S., Gabriel, Stacey B., Getz, Gad, Garraway, Levi A., Chin, Lynda
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2012
• Subjects: Amino Acid Sequence; carcinogenicity; Cells, Cultured; Exome; genes; Genome-Wide Association Study; Humans; Melanocytes - metabolism; melanoma; Melanoma - genetics; Models, Molecular; Molecular Sequence Data; Mutagenesis; mutagenicity; mutation; pathogenesis; Proto-Oncogene Proteins B-raf - genetics; rac1 GTP-Binding Protein - genetics; Sequence Alignment; surveys; ultraviolet radiation; Ultraviolet Rays

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure. We developed a permutation-based framework to address this challenge, employing mutation data from intronic sequence...