UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China

• Published in: BMC pediatrics Vol. 21; no. 1; p. 259
• Main Authors: Yang, Hui, Lin, Fen, Chen, Zi-Kai, Zhang, Lin, Xu, Jia-Xin, Wu, Yong-Hao, Gu, Jing-Ying, Ma, Yu-Bin, Li, Jian-Dong, Yang, Li-Ye
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.06.2021; BioMed Central; BMC
• Subjects: Antibodies; Bilirubin; Birth weight; China; Compatibility testing (Hematology); Complications and side effects; Disease; Electronic health records; Gender; Gene mutations; Genetic aspects; Gestational age; Glucuronosyltransferase - genetics; Haplotypes; Health aspects; Hospitals; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Neonatal - genetics; Infant, Newborn; Isoenzymes; Light therapy; Medical laboratories; Medical records; Mutation; Neonatal jaundice; Newborn babies; Pediatric research; Pediatrics; Polymorphism; Retrospective Studies; Serology; Uridine diphosphate; China; Asia

Neonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form. A retrospective study was conducted to review clinical information o...