Effect of first-line biologic initiation on glucocorticoid exposure in children hospitalized with new-onset systemic juvenile idiopathic arthritis: emulation of a pragmatic trial using observational data

• Published in: Pediatric rheumatology online journal Vol. 19; no. 1; pp. 109 - 8
• Main Authors: Peterson, Rosemary G., Xiao, Rui, Katcoff, Hannah, Fisher, Brian T., Weiss, Pamela F.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.07.2021; BioMed Central; BMC
• Subjects: Arthritis; Arthritis, Juvenile - drug therapy; Biological Products - therapeutic use; Biological therapy; Child; Child, Preschool; Clinical trials; Corticosteroids; Female; Glucocorticoids; Glucocorticoids - therapeutic use; Hospital patients; Hospitalization; Humans; Juvenile systemic arthritis; Laboratories; Male; Patients; Pediatrics; Population; Retrospective Studies; Rheumatoid arthritis; Rheumatology; Treatment Outcome; Trends; Glucocorticoids; Juvenile systemic arthritis; Biological therapy

Glucocorticoid exposure is a significant driver of morbidity in children with systemic juvenile idiopathic arthritis (sJIA). We determined the effect of early initiation of biologic therapy (IL-1 or IL-6 inhibition) on glucocorticoid exposure in hospitalized patients with new-onset sJIA. We emulated...