Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

• Published in: European journal of medical research Vol. 28; no. 1; pp. 82 - 14
• Main Authors: Chen, Yung-Che, Lin, I-Chun, Su, Mao-Chang, Hsu, Po-Yuan, Hsiao, Chang-Chun, Hsu, Te-Yao, Liou, Chia-Wei, Chen, Yu-Mu, Chin, Chien-Hung, Wang, Ting-Ya, Chang, Jen-Chieh, Lin, Yong-Yong, Lee, Chiu-Ping, Lin, Meng-Chih
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2023; BioMed Central; BMC
• Subjects: Apoptosis; Apoptosis - genetics; Autophagy; Autophagy - genetics; Autophagy-Related Protein 5 - genetics; Body mass index; Cytotoxicity; DNA methylation; DNA Methylation - genetics; Electroencephalography; Epigenesis, Genetic; Epigenetic inheritance; Gene expression; Genes; Homeostasis; Humans; Hypertension; Hypoxia; Intermittent hypoxia with re-oxygenation; Ischemia; Kinases; Leukocytes, Mononuclear; Lymphocytes; Medical law; Mesenchymal stem cell; Methylation; Neutrophils; Obstructive sleep apnea; Oxidative stress; Oxidative Stress - genetics; Proteins; Rapamycin; Sleep apnea; Sleep apnea syndromes; Stem cells; T cells; United States > US; Mesenchymal stem cell; DNA methylation; Rapamycin; Intermittent hypoxia with re-oxygenation; Autophagy; Obstructive sleep apnea

Autophagy is a catabolic process that recycles damaged organelles and acts as a pro-survival mechanism, but little is known about autophagy dysfunction and epigenetic regulation in patients with obstructive sleep apnea (OSA). Protein/gene expressions and DNA methylation levels of the autophagy-relat...