Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

• Published in: Nature genetics Vol. 42; no. 9; pp. 781 - 785
• Main Authors: Hamza, Taye H, Zabetian, Cyrus P, Tenesa, Albert, Laederach, Alain, Montimurro, Jennifer, Yearout, Dora, Kay, Denise M, Doheny, Kimberly F, Paschall, Justin, Pugh, Elizabeth, Kusel, Victoria I, Collura, Randall, Roberts, John, Griffith, Alida, Samii, Ali, Scott, William K, Nutt, John, Factor, Stewart A, Payami, Haydeh
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2010; Nature Publishing Group
• Subjects: 631/1647/2217/2138; 631/208/727/2000; 692/699/375/365/1718; Adult; Age of Onset; Aged; Aged, 80 and over; Agriculture; Animal Genetics and Genomics; Antiparkinsonian agents; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic Linkage; Genetic Predisposition to Disease; Genetic Variation - physiology; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Health aspects; Histocompatibility antigens; HLA Antigens - genetics; HLA histocompatibility antigens; Human Genetics; Humans; letter; Male; Medical sciences; Meta-Analysis as Topic; Middle Aged; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Odds Ratio; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Parkinson's disease; Physiological aspects; Risk factors; Single nucleotide polymorphisms; Young Adult; United States; Nervous system diseases; Late; Genetic variability; Sporadic; Genetic variant; Central nervous system disease; Parkinson disease; Degenerative disease; Cerebral disorder; Extrapyramidal syndrome

Haydeh Payami and colleagues report results of a genome-wide association study for Parkinson's disease. They identify common variants in the HLA region associated with the late-onset sporadic form of the disease and replicate published associations with SNCA , MAPT and GAK . Parkinson's di...