Haploidentical donor is preferred over matched sibling donor for pre-transplantation MRD positive ALL: a phase 3 genetically randomized study

• Published in: Journal of hematology and oncology Vol. 13; no. 1; pp. 27 - 13
• Main Authors: Chang, Ying-Jun, Wang, Yu, Xu, Lan-Ping, Zhang, Xiao-Hui, Chen, Huan, Chen, Yu-Hong, Wang, Feng-Rong, Wei-Han, Sun, Yu-Qian, Yan, Chen-Hua, Tang, Fei-Fei, Mo, Xiao-Dong, Liu, Yan-Rong, Liu, Kai-Yan, Huang, Xiao-Jun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.03.2020; BioMed Central; BMC
• Subjects: Acute lymphoblastic leukemia; Acute lymphocytic leukemia; Adolescent; Adult; Antitumor activity; Bone marrow; Cancer research; Chemotherapy; Child; Child, Preschool; Comparative analysis; Cytomegalovirus; Diseases; Donor Selection; Donors; Female; Flow cytometry; Haploidentical donor transplantation; Health aspects; Hematology; Humans; Leukemia; Lymphatic leukemia; Lymphocytic leukemia; Male; Matched sibling donor transplantation; Measurable residual disease; Middle Aged; Mortality; Multivariate analysis; Neoplasm, Residual - genetics; Neoplasm, Residual - therapy; Oncology; Patients; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Prospective Studies; Siblings; Stem Cell Transplantation - methods; Studies; Surgery; Survival; Tissue Donors; Transplantation; Transplantation, Haploidentical - methods; Transplants & implants; Young Adult; Matched sibling donor transplantation; Haploidentical donor transplantation; Acute lymphoblastic leukemia; Measurable residual disease; Donor selection

Previous reports suggest a benefit associated with haploidentical donor transplantation (HIDT) compared to matched sibling donor transplantation (MSDT) in certain contexts, and the choice of optimal candidates warrants further investigation. We designed a prospective genetically randomized study to...