Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

• Published in: Journal of hematology and oncology Vol. 15; no. 1; p. 61
• Main Authors: Tie, Yan, Tang, Fan, Wei, Yu-Quan, Wei, Xia-Wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.05.2022; BioMed Central; BMC
• Subjects: Adoptive transfer; Angiogenesis; Antigens; Biomarkers; Bone marrow; Cancer; Cytokines; Dendritic cells; Development and progression; Gene expression; Genotype & phenotype; Health aspects; Hematology; Humans; Immune Checkpoint Inhibitors; Immunoregulation; Immunosuppressive cells; Immunosuppressive cellular cytokines; Immunotherapy; Leukocytes (neutrophilic); Lymphocytes; Lymphocytes T; Macrophages; Medical prognosis; Metastasis; Neoplasms - drug therapy; Neutrophils; Oncology; Patients; Phenotypes; Review; T cells; T-Lymphocytes, Regulatory; Therapeutic applications; Therapeutic targets; Tumor cells; Tumor immune microenvironment; Tumor Microenvironment; Tumors; Vascular endothelial growth factor; Tumor immune microenvironment; Immunosuppressive cells; Immunosuppressive cellular cytokines; Immunotherapy

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some patients are refractory or resistant to these therapies, and the mechanisms underlying tumor immune resistance have not been ful...