Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers

• Published in: Journal of controlled release Vol. 143; no. 3; pp. 290 - 301
• Main Authors: Batrakova, Elena V., Li, Shu, Brynskikh, Anna M., Sharma, Amit K., Li, Yili, Boska, Michael, Gong, Nan, Mosley, R. Lee, Alakhov, Valery Yu, Gendelman, Howard E., Kabanov, Alexander V.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 10.05.2010; Elsevier
• Subjects: Adenosine Triphosphate - metabolism; Animals; Apoptosis - drug effects; Body Weight - drug effects; Cancer; Carcinoma, Lewis Lung - drug therapy; Carcinoma, Lewis Lung - metabolism; Carcinoma, Lewis Lung - pathology; Cell Line, Tumor; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - therapeutic use; Drug Resistance, Neoplasm - drug effects; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; Leukemia, T-Cell - drug therapy; Leukemia, T-Cell - metabolism; Leukemia, T-Cell - pathology; MDR; Metabolism; Mice; Mice, Inbred C57BL; Pluronic; Poloxamer - pharmacology; Tomography, Emission-Computed, Single-Photon; Pluronic; MDR; Metabolism; Doxorubicin; Cancer

Cancer chemotherapy is believed to be impeded by multidrug resistance (MDR). Pluronic (triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO- b-PPO- b-PEO) were previously shown to sensitize MDR tumors to antineoplastic agents. This study uses animal models of Lewis...