Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling - Gunner, Georgia; Cheadle, Lucas; Johnson, Kasey M.; Ayata, Pinar; Badimon, Ana; Mondo, Erica; Nagy, M. Aurel; Liu, Liwang; Bemiller, Shane M.; Kim, Ki-Wook; Lira, Sergio A.; Lamb, Bruce T.; et al. (Nature neuroscience, 2019)
Keywords: 14; 14/19; 38; 38/91; 631/378; 631/378/2596; 631/378/340; 631/378/3920; 631/378/87; 64; 64/110; 64/60; 96; ADAM10 Protein - antagonists & inhibitors; ADAM10 Protein - genetics; ADAM10 Protein - physiology; Alzheimer's disease; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - physiology; Analysis; Animal Genetics and Genomics; Animals; Apoptosis; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain research; Cell Count; Chemokine CX3CL1 - physiology; Complement receptor 3; Control; CX3C Chemokine Receptor 1 - deficiency; CX3C Chemokine Receptor 1 - genetics; CX3C Chemokine Receptor 1 - physiology; CX3CR1 protein; Defects; Female; Fractalkine; Gene Expression Regulation; Gene sequencing; Ligands; Male; Medicine; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - physiology; Metalloproteinase; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfluidic Analytical Techniques; Microglia; Microglia - physiology; Neural networks; Neural transmission; Neurobiology; Neurons; Neurosciences; Physiological aspects; Ribonucleic acid; RNA; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Sensorimotor Cortex - metabolism; Sensorimotor Cortex - pathology; Sensorimotor Cortex - physiopathology; Signal Transduction - physiology; Signaling; Single-Cell Analysis; Synapse elimination; Synapses; Touch - physiology; Transcriptome; Vibrissae; Vibrissae - injuries; Vibrissae - physiology; United States