Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands

• Published in: BMC medical genetics Vol. 18; no. 1; pp. 109 - 12
• Main Authors: Karmakar, Arijit, Goswami, Rishov, Saha, Tanusree, Maitra, Subhamita, Roychowdhury, Anirban, Panda, Chinmay Kumar, Sinha, Swagata, Ray, Anirban, Mohanakumar, Kochupurackal P., Rajamma, Usha, Mukhopadhyay, Kanchan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.10.2017; BioMed Central; BMC
• Subjects: ADHD; Age; Alleles; Amine oxidase (flavin-containing); Analysis; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - genetics; Attention deficit hyperactivity disorder; Behavior; Behavioral trait; Children; Data processing; Development and progression; Diagnostic and Statistical Manual of Mental Disorders; DNA sequencing; Dopamine; Etiology; European Continental Ancestry Group - genetics; Families & family life; Female; Females; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic variation; Genotyping; Genotyping Techniques; Haplotypes; Heritability; Humans; Hyperactivity; Impulsive behavior; Impulsivity; Isoenzymes; Male; MAOA; MAOB; Maternal transmission; Mental disorders; Metabolism; Minority & ethnic groups; Mitochondria; Monoamine oxidase; Monoamine Oxidase - genetics; Neurosciences; Neurotransmitters; Norepinephrine; Physiological aspects; Pilot Projects; Pregnancy; Problem Behavior - psychology; Serotonin; Statistical analysis; Statistics; India; ADHD; Maternal age; Genotyping; MAOB; MAOA; Linkage disequilibrium; Behavioral trait; Indo-Caucasoid population; Maternal transmission

Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate inattention, hyperactivity, and impulsivity. Symptom severity varies widely and boys are diagnosed more frequently than girls. ADHD probands were re...