Link prediction in drug-target interactions network using similarity indices

• Published in: BMC bioinformatics Vol. 18; no. 1; p. 39
• Main Authors: Lu, Yiding, Guo, Yufan, Korhonen, Anna
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.01.2017; BioMed Central
• Subjects: Computer Simulation; Databases, Factual; Drug interactions; Drug Repositioning - instrumentation; Drug Repositioning - methods; Observations; Support Vector Machine

In silico drug-target interaction (DTI) prediction plays an integral role in drug repositioning: the discovery of new uses for existing drugs. One popular method of drug repositioning is network-based DTI prediction, which uses complex network theory to predict DTIs from a drug-target network. Curre...