Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

• Published in: Clinical immunology (Orlando, Fla.) Vol. 149; no. 3; pp. 365 - 378
• Main Authors: Zhang, Li, Bertucci, Anne M., Ramsey-Goldman, Rosalind, Harsha-Strong, Elizabeth Randall, Burt, Richard K., Datta, Syamal K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013
• Subjects: Adult; Allergy and Immunology; Anti-Inflammatory Agents - pharmacology; Antigens, CD - genetics; Antigens, CD - immunology; Autoantibodies - biosynthesis; Autoimmunity; Autoimmunity - drug effects; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Epitopes; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - immunology; Gene Expression Regulation; Histones - chemistry; Histones - immunology; Human; Humans; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Lymphocyte Activation; Male; Middle Aged; Nucleosomes - chemistry; Nucleosomes - immunology; Peptide epitopes; Peptides - immunology; Peptides - pharmacology; Primary Cell Culture; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - immunology; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - immunology; Signal Transduction; Smad2 Protein - genetics; Smad2 Protein - immunology; Smad3 Protein - genetics; Smad3 Protein - immunology; Systemic lupus erythematosus; T cells; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - pathology; Tolerance; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - immunology; Human; Autoimmunity; TSA; iTreg; RAPA; H; 1,25(OH)2D3; Tolerance; T cells; SLE; RA; Peptide epitopes; Systemic lupus erythematosus; DEX; HCQ; APG; ODN; LAP; HSCT; 1,25-dihydroxyvitamin D3; systemic lupus erythematosus; hydroxychloroquine; Apigenin; hematopoietic stem cell transplantation; Trichostatin A; induced regulatory T cells; dexamethasone; 1,25(OH) 2D 3; Rapamycin; oligonucleotide; latency associated peptide; retinoic acid; histone; 1,25(OH)D

Low-dose tolerance therapy with nucleosomal histone peptide epitopes blocks lupus disease in mouse models, but effect in humans is unknown. Herein, we found that CD4+CD25highFoxP3+ or CD4+CD45RA+FoxP3low T-cells, and CD8+CD25+FoxP3+ T-cells were all induced durably in PBMCs from inactive lupus patie...