Altered central and blood glutathione in Alzheimer’s disease and mild cognitive impairment: a meta-analysis

• Published in: Alzheimer's research & therapy Vol. 14; no. 1; pp. 23 - 17
• Main Authors: Chen, Jinghan Jenny, Thiyagarajah, Mathura, Song, Jianmeng, Chen, Clara, Herrmann, Nathan, Gallagher, Damien, Rapoport, Mark J., Black, Sandra E., Ramirez, Joel, Andreazza, Ana C., Oh, Paul, Marzolini, Susan, Graham, Simon J., Lanctôt, Krista L.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.02.2022; BioMed Central; BMC
• Subjects: Alzheimer disease; Alzheimer Disease - psychology; Alzheimer's disease; Animal cognition; Antioxidant; Antioxidants; Bias; Biomarkers; Brain; Brain - metabolism; Cognitive ability; Cognitive Dysfunction - psychology; Cognitive impairment; Complications and side effects; Composition; Dementia; Editorials; Glutathione; Glutathione - metabolism; Health aspects; Human subjects; Humans; Meta-analysis; Neurodegeneration; Oxidative Stress; Plasma; Proteins; Canada; Oxidative stress; Alzheimer disease; Biomarkers; Antioxidant; Cognitive impairment; Glutathione; Meta-analysis

Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD) and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive. Re...