Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

• Published in: NeuroImage (Orlando, Fla.) Vol. 45; no. 4; pp. 1107 - 1116
• Main Authors: Langbaum, Jessica B.S., Chen, Kewei, Lee, Wendy, Reschke, Cole, Bandy, Dan, Fleisher, Adam S., Alexander, Gene E., Foster, Norman L., Weiner, Michael W., Koeppe, Robert A., Jagust, William J., Reiman, Eric M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2009; Elsevier Limited
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Cerebral Cortex - diagnostic imaging; Cognition Disorders - diagnostic imaging; Cognitive ability; Dementia; Female; Fluorodeoxyglucose F18; Humans; Male; MCI; Medical imaging; Middle Aged; MMSE; Positron emission tomography; Positron-Emission Tomography - methods; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Studies; MCI; Alzheimer's disease; Positron emission tomography; MMSE

In mostly small single-center studies, Alzheimer's disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl). The AD Neuroimaging Initiative (ADNI) i...