Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

• Published in: Journal of hematology and oncology Vol. 14; no. 1; pp. 200 - 20
• Main Authors: Lu, Jia-Cheng, Zhang, Peng-Fei, Huang, Xiao-Yong, Guo, Xiao-Jun, Gao, Chao, Zeng, Hai-Ying, Zheng, Yi-Min, Wang, Si-Wei, Cai, Jia-Bin, Sun, Qi-Man, Shi, Ying-Hong, Zhou, Jian, Ke, Ai-Wu, Shi, Guo-Ming, Fan, Jia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.11.2021; BioMed Central; BMC
• Subjects: Adenosine; Adenosine - metabolism; Analysis; Animal models; Antibodies; Apoptosis; ATP–adenosine pathway; Biopsy; Blood; Cancer; Cancer immunotherapy; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Care and treatment; CD39; CD73 antigen; CD8 antigen; Cell Line, Tumor; DNA sequencing; Drug Resistance, Neoplasm; Exosomal circRNA; Exosomes; Flow cytometry; Hematology; Hepatocellular carcinoma; Hepatoma; Humans; Immune checkpoint; Immune Checkpoint Inhibitors - pharmacology; Immune status; Immunofluorescence; Immunoprecipitation; Immunosuppression; Immunotherapy; Internalization; Laboratory animals; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Lymphocytes T; Macrophage; Macrophages; Medical prognosis; Nucleotide sequencing; Oncology; Patients; PD-1 protein; Ribonucleic acid; RNA; RNA sequencing; Signal Transduction - drug effects; Statistical analysis; T cells; Tumor microenvironment; Tumors; Ultracentrifugation; China; CD39; Hepatocellular carcinoma; ATP–adenosine pathway; Exosomal circRNA; Macrophage

Immune checkpoint blockade resistance narrows the efficacy of cancer immunotherapies, but the underlying mechanism remains elusive. Delineating the inherent mechanisms of anti-PD1 resistance is important to improve outcome of patients with advanced HCC. The level of cricTMEM181 was measured in HCC p...