Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma - Lu, Jia-Cheng; Zhang, Peng-Fei; Huang, Xiao-Yong; Guo, Xiao-Jun; Gao, Chao; Zeng, Hai-Ying; Zheng, Yi-Min; Wang, Si-Wei; Cai, Jia-Bin; Sun, Qi-Man; Shi, Ying-Hong; Zhou, Jian; et al. (Journal of hematology and oncology, 2021)
Keywords: Adenosine; Adenosine - metabolism; Analysis; Animal models; Antibodies; Apoptosis; ATP–adenosine pathway; Biopsy; Blood; Cancer; Cancer immunotherapy; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Care and treatment; CD39; CD73 antigen; CD8 antigen; Cell Line, Tumor; DNA sequencing; Drug Resistance, Neoplasm; Exosomal circRNA; Exosomes; Flow cytometry; Hematology; Hepatocellular carcinoma; Hepatoma; Humans; Immune checkpoint; Immune Checkpoint Inhibitors - pharmacology; Immune status; Immunofluorescence; Immunoprecipitation; Immunosuppression; Immunotherapy; Internalization; Laboratory animals; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Lymphocytes T; Macrophage; Macrophages; Medical prognosis; Nucleotide sequencing; Oncology; Patients; PD-1 protein; Ribonucleic acid; RNA; RNA sequencing; Signal Transduction - drug effects; Statistical analysis; T cells; Tumor microenvironment; Tumors; Ultracentrifugation; China; CD39; Hepatocellular carcinoma; ATP–adenosine pathway; Exosomal circRNA; Macrophage