Predicting the artificial immunity induced by RUTI® vaccine against tuberculosis using universal immune system simulator (UISS)

• Published in: BMC bioinformatics Vol. 20; no. Suppl 6; pp. 504 - 10
• Main Authors: Pennisi, Marzio, Russo, Giulia, Sgroi, Giuseppe, Bonaccorso, Angela, Parasiliti Palumbo, Giuseppe Alessandro, Fichera, Epifanio, Mitra, Dipendra Kumar, Walker, Kenneth B, Cardona, Pere-Joan, Amat, Merce, Viceconti, Marco, Pappalardo, Francesco
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.12.2019; BioMed Central; BMC
• Subjects: Activation; Analysis; Antibiotics; Antitubercular agents; Bacilli; Chemotherapy; Chronic diseases; Chronic illnesses; Chronic infection; Clinical trials; Computational Biology; Computational modeling framework; Computer applications; Computer Simulation; Consortia; Control; Developing countries; Development and progression; Diseases; Drug resistance; Granuloma; Health aspects; Human behavior; Humans; Immune response; Immune system; Immunity; Immunity (Disease); Immunology; Immunosuppressive agents; In silico clinical trials; India; Infections; Infrastructure (Economics); Isoniazid; LDCs; Lungs; Medical research; Microbial drug resistance; Mortality; Multidrug resistance; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Public health; Public health movements; Simulation; Software; Subpopulations; Therapeutic applications; Therapeutic strategies; Tuberculosis; Tuberculosis - immunology; Tuberculosis vaccines; Tuberculosis Vaccines - immunology; Vaccination; Vaccine; Vaccine development; Vaccines; World population; India; Vaccine; Tuberculosis; Computational modeling framework; Immunity; In silico clinical trials; Therapeutic strategies

Tuberculosis (TB) represents a worldwide cause of mortality (it infects one third of the world's population) affecting mostly developing countries, including India, and recently also developed ones due to the increased mobility of the world population and the evolution of different new bacteria...