Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study

• Published in: Bone (New York, N.Y.) Vol. 90; pp. 181 - 184
• Main Authors: Napoli, Nicola, Schafer, Anne L., Lui, Li-Yung, Cauley, Jane A., Strotmeyer, Elsa S., Le Blanc, Erin S., Hoffman, Andrew R., Lee, Christine G., Black, Dennis M., Schwartz, Ann V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2016
• Subjects: Aged; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Humans; Incidence; Male; Older men; Orthopedics; Osteoporotic Fractures - blood; Type 2 diabetes; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Type 2 diabetes; Vitamin D; Older men
• ISSN: 8756-3282; 1873-2763; 1873-2763
• DOI: 10.1016/j.bone.2016.07.001

The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m2±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73–1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85–1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. •The association between vitamin D status and diabetes risk has been investigated in several studies with inconsistent results.•In our prospective cohort study, 25(OH)D levels are not associated with incident T2D in older men.•It remains to be investigated if vitamin D supplementation decreases diabetes risk.