Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study
The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) i...
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| Published in | Bone (New York, N.Y.) Vol. 90; pp. 181 - 184 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.09.2016
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| Abstract | The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002.
Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m2±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73–1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85–1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles.
In conclusion, 25(OH)D levels were not associated with incident T2D in older men.
•The association between vitamin D status and diabetes risk has been investigated in several studies with inconsistent results.•In our prospective cohort study, 25(OH)D levels are not associated with incident T2D in older men.•It remains to be investigated if vitamin D supplementation decreases diabetes risk. |
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| AbstractList | The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men ( greater than or equal to 65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 ( plus or minus 5.7) years old, had a mean BMI in the overweight range (27.2kg/m2 plus or minus 3.6) and had total serum 25(OH)D of 26.1ng/ml ( plus or minus 8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73-1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85-1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m(2)±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73-1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85-1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men.The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m(2)±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73-1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85-1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. Abstract The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥ 65 years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4 years. At baseline, participants were, on average, 73.3 (± 5.7) years old, had a mean BMI in the overweight range (27.2 kg/m2 ± 3.6) and had total serum 25(OH)D of 26.1 ng/ml (± 8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73–1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85–1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m2±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73–1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85–1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. •The association between vitamin D status and diabetes risk has been investigated in several studies with inconsistent results.•In our prospective cohort study, 25(OH)D levels are not associated with incident T2D in older men.•It remains to be investigated if vitamin D supplementation decreases diabetes risk. The association between vitamin D status and diabetes risk has is inconsistent among observational studies, and most of the available studies have been in women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65 years of age) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, Body Mass Index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4 years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2 Kg/m 2 ±3.6) and had total serum 25(OH)D of 26.1 ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87 95% CI: 0.73 – 1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85 – 1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m(2)±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73-1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85-1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men. |
| Author | Le Blanc, Erin S. Cauley, Jane A. Black, Dennis M. Lui, Li-Yung Hoffman, Andrew R. Strotmeyer, Elsa S. Schwartz, Ann V. Schafer, Anne L. Napoli, Nicola Lee, Christine G. |
| AuthorAffiliation | 7 Center for Health Research NW, Kaiser Permanente, USA 5 California Pacific Medical Center, San Francisco, CA, USA 3 University of California, San Francisco, CA, USA 8 Stanford University, USA 2 Division of Genetic and Cell Biology, San Raffaele Scientific Institute, Milan, Italy 9 Veterans Affairs Health Care System, Portland, OR, USA 6 Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, Kaiser Permanente, USA 1 Università Campus Bio-Medico di Roma, San Raffaele Scientific Institute, Milan, Italy Diabetes and Bone Network, San Raffaele Scientific Institute, Milan, Italy 4 San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA |
| AuthorAffiliation_xml | – name: 3 University of California, San Francisco, CA, USA – name: 1 Università Campus Bio-Medico di Roma, San Raffaele Scientific Institute, Milan, Italy – name: 9 Veterans Affairs Health Care System, Portland, OR, USA – name: 4 San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA – name: 6 Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, Kaiser Permanente, USA – name: Diabetes and Bone Network, San Raffaele Scientific Institute, Milan, Italy – name: 5 California Pacific Medical Center, San Francisco, CA, USA – name: 2 Division of Genetic and Cell Biology, San Raffaele Scientific Institute, Milan, Italy – name: 8 Stanford University, USA – name: 7 Center for Health Research NW, Kaiser Permanente, USA |
| Author_xml | – sequence: 1 givenname: Nicola surname: Napoli fullname: Napoli, Nicola email: n.napoli@unicampus.it organization: Università Campus Bio-Medico di Roma, Italy – sequence: 2 givenname: Anne L. surname: Schafer fullname: Schafer, Anne L. organization: University of California, San Francisco, CA, USA – sequence: 3 givenname: Li-Yung surname: Lui fullname: Lui, Li-Yung organization: California Pacific Medical Center, San Francisco, CA, USA – sequence: 4 givenname: Jane A. surname: Cauley fullname: Cauley, Jane A. organization: Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, USA – sequence: 5 givenname: Elsa S. surname: Strotmeyer fullname: Strotmeyer, Elsa S. organization: Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, USA – sequence: 6 givenname: Erin S. surname: Le Blanc fullname: Le Blanc, Erin S. organization: Center for Health Research NW, Kaiser Permanente, USA – sequence: 7 givenname: Andrew R. surname: Hoffman fullname: Hoffman, Andrew R. organization: Stanford University, USA – sequence: 8 givenname: Christine G. surname: Lee fullname: Lee, Christine G. organization: Veterans Affairs Health Care System, Portland, OR, USA – sequence: 9 givenname: Dennis M. surname: Black fullname: Black, Dennis M. organization: University of California, San Francisco, CA, USA – sequence: 10 givenname: Ann V. surname: Schwartz fullname: Schwartz, Ann V. organization: University of California, San Francisco, CA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27393241$$D View this record in MEDLINE/PubMed |
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| Snippet | The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women.... Abstract The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been... The association between vitamin D status and diabetes risk has is inconsistent among observational studies, and most of the available studies have been in... |
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| SubjectTerms | Aged Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Humans Incidence Male Older men Orthopedics Osteoporotic Fractures - blood Type 2 diabetes Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood |
| Title | Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study |
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