Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data

• Published in: BMC bioinformatics Vol. 20; no. S7; pp. 195 - 39
• Main Authors: Hao, Yang, Li, Daixi, Xu, Yong, Ouyang, Jian, Wang, Yongkun, Zhang, Yuqi, Li, Baoguo, Xie, Lu, Qin, Guangrong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.05.2019; BioMed Central; BMC
• Subjects: Analysis; Arachidonic acid; Backup software; Biological markers; Biomarkers; Biomarkers, Tumor - genetics; Cancer; Carcinogenesis; CD36 antigen; Cholesterol; Commonality; Computational Biology - methods; Correlation analysis; Criminal investigation; Crosstalk; Deoxyribonucleic acid; DNA; DNA binding proteins; DNA Methylation; Fatty acids; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes; Humans; Immune response; Immune system; Immunosuppression; Immunotherapy; Lipid metabolism; Lipid Metabolism - genetics; Lipids; Metabolism; Metabolites; Methylation; Microenvironments; Multiple omics analysis; Mutation; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Novels; Ovarian cancer; Pan-cancer; Peroxisome proliferator-activated receptors; Therapeutic applications; Transcription (Genetics); Transcription factors; Transcriptome; Tumor immune micro-environment; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumorigenesis; Tumors; Unsaturated fatty acids; China; Tumor immune micro-environment; Lipid metabolism; Pan-cancer; Multiple omics analysis

Lipid metabolism reprogramming is a hallmark for tumor which contributes to tumorigenesis and progression, but the commonality and difference of lipid metabolism among pan-cancer is not fully investigated. Increasing evidences suggest that the alterations in tumor metabolism, including metabolite ab...