Crosstalk between Red Blood Cells and the Immune System and Its Impact on Atherosclerosis

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 8
• Main Authors: Buttari, Brigitta, Riganò, Rachele, Profumo, Elisabetta
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Atherosclerosis; Atherosclerosis - immunology; Atherosclerosis - metabolism; Atherosclerosis - pathology; Blood; CD47 Antigen - metabolism; Cell growth; Cell Proliferation; Cytokines; Erythrocytes; Erythrocytes - immunology; Erythrocytes - metabolism; Erythrocytes - pathology; Glycophorin - metabolism; Health aspects; Humans; Immune system; Immune System - metabolism; Immune System - pathology; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Oxidative Stress; Physiological aspects; Review; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology

Atherosclerosis is a chronic multifactorial disease of the arterial wall characterized by inflammation, oxidative stress, and immune system activation. Evidence exists on a pathogenic role of oxidized red blood cells (RBCs) accumulated in the lesion after intraplaque hemorrhage. This review reports...