Identification of viral protein R of human immunodeficiency virus-1 (HIV) and interleukin-6 as risk factors for malignancies in HIV-infected individuals: A cohort study

• Published in: PloS one Vol. 19; no. 1; p. e0296502
• Main Authors: Matsunaga, Akihiro, Ando, Naokatsu, Yamagata, Yuko, Shimura, Mari, Gatanaga, Hiroyuki, Oka, Shinichi, Ishizaka, Yukihito
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2024; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Analysis; Antibodies; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Biology and Life Sciences; Blood; Blood circulation; Cancer; Care and treatment; Cell cycle; Cervical cancer; Cytokines; Development and progression; DNA damage; Dosage and administration; Enzymes; Gastric cancer; Genotoxicity; Hepatitis B; Hepatitis C; Highly active antiretroviral therapy; HIV; HIV (Viruses); HIV infection; HIV patients; Human immunodeficiency virus; Immune system; Immunoassays; Immunoglobulin G; Infections; Inflammation; Interleukin 6; Interleukins; Lymphoma; Malignancy; Medical prognosis; Medicine and Health Sciences; Oxidative stress; Pancreatic cancer; Prevention; Prostate; Prostate cancer; Proteins; Regression analysis; Risk factors; Tumors; Viral proteins; Viruses; Vpr protein; Japan; Germany

Despite effective antiretroviral therapy, patients with human immunodeficiency virus type-1 (HIV) suffer from a high frequency of malignancies, but related risk factors remain elusive. Here, we focused on blood-circulating viral protein R (Vpr) of HIV, which induces proinflammatory cytokine producti...