Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease - Yan, Michael H.; Wang, Xinglong; Zhu, Xiongwei (Free radical biology & medicine, 2013)
Keywords: Alzheimer disease; Alzheimer Disease - etiology; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Cell Death; death; Free radicals; genes; heritability; homeostasis; Humans; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial DNA; Mitochondrial dynamics; Mitochondrial dysfunction; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurons - metabolism; Neurons - pathology; Oxidative stress; Oxidative Stress - genetics; Parkinson disease; Parkinson Disease - etiology; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; pathogenesis; pathophysiology; reactive oxygen species; Reactive Oxygen Species - metabolism; APP; Oxidative stress; PS; mtDNA; Alzheimer disease; Mitochondrial dynamics; ApoE4; Parkinson disease; OXPHOS; Mitochondrial DNA; Aβ; Mfn; SNP; LRRK2 or PARK8; OPA-1; AD; Mitochondrial dysfunction; Free radicals; PINK1 or PARK6; DLP1, aka Drp1; SOD; COX; OMM; MMP; MERRF; PD; ADDL; ETC; ROS; LHON; MPTP; outer mitochondrial membrane; cytochrome c oxidase; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyradine; Leber's hereditary optic neuropathy; presenilin; mitochondrial membrane potential; amyloid-β; myoclonic epilepsy with red ragged fibers syndrome; oxidative phosphorylation; dynamin-like protein 1; PTEN-induced putative kinase; superoxide dismutase; apolipoprotein E; reactive oxygen species; optic atrophy protein 1; single-nucleotide polymorphism; leucine-rich repeat kinase 2; electron transport chain; Aβ-derived diffusible ligand; amyloid-β protein precursor; mitofusin