Models based on nucleic acid methylation regulators will contribute to facilitating cancer precision medicine

Background With the development of molecular biology techniques, it is possible to explore the tumorigenesis and cancer development mechanisms and intrinsic characteristics of single cancer types from the perspectives of chromosome, genome, transcriptome, protein expression, and epigenetics, and on...

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Published inBMC medicine Vol. 19; no. 1; pp. 295 - 3
Main Author Zhang, Wen
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.12.2021
BioMed Central
BMC
Subjects
5mC
Acids
Biomarkers
Bladder cancer
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Chromosomes
DNA methylation
Drug therapy
Epigenetics
Gene expression
Genetic aspects
Genomes
Health aspects
Heterogeneity
Humans
Immunotherapy
Immunotherapy response
Lung cancer
Lung cancer, Small cell
m6A
Medical prognosis
Medical research
Methylation
Methylation regulator
Molecular biology
Neoplasms - drug therapy
Neoplasms - genetics
Nucleic acids
Phenotypes
Precision Medicine
Prognosis
RNA, Neoplasm - metabolism
Small-cell lung cancer
Transcriptomes
Tumorigenesis
China
Precision medicine
m6A
5mC
Immunotherapy response
Bladder cancer
Small-cell lung cancer
Methylation regulator
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Abstract Background With the development of molecular biology techniques, it is possible to explore the tumorigenesis and cancer development mechanisms and intrinsic characteristics of single cancer types from the perspectives of chromosome, genome, transcriptome, protein expression, and epigenetics, and on this basis, molecular subtypes can be classified [1, 2]. [...]the 5mC score was significantly related to the cancer stemness and could reflect TME heterogeneity. Usually, a higher cancer stemness indicates a decrease in anti-cancer immunity and lower ICB response. [...]the 5mC score could effectively stratify the immune phenotypes of BLCA.
AbstractList Keywords: 5mC, m.sup.6A, Methylation regulator, Bladder cancer, Small-cell lung cancer, Immunotherapy response, Precision medicine
Background With the development of molecular biology techniques, it is possible to explore the tumorigenesis and cancer development mechanisms and intrinsic characteristics of single cancer types from the perspectives of chromosome, genome, transcriptome, protein expression, and epigenetics, and on this basis, molecular subtypes can be classified [1, 2]. [...]the 5mC score was significantly related to the cancer stemness and could reflect TME heterogeneity. Usually, a higher cancer stemness indicates a decrease in anti-cancer immunity and lower ICB response. [...]the 5mC score could effectively stratify the immune phenotypes of BLCA.
ArticleNumber 295
Audience Academic
Author Zhang, Wen
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Cites_doi 10.1186/s12916-021-02163-6
10.3389/fphar.2021.690057
10.1186/s12916-021-02148-5
10.15252/embj.2020104514
10.1186/s12943-019-1099-7
10.1016/j.cell.2017.05.045
10.1016/j.trecan.2020.02.003
10.1158/0008-5472.CAN-18-2965
10.1097/PPO.0000000000000281
10.1039/c6cs00599c
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Issue 1
Keywords Precision medicine
m6A
5mC
Immunotherapy response
Bladder cancer
Small-cell lung cancer
Methylation regulator
Language English
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References 2171_CR9
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  start-page: 690057
  year: 2021
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  publication-title: Front Pharmacol.
  doi: 10.3389/fphar.2021.690057
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  doi: 10.1186/s12916-021-02148-5
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  doi: 10.1186/s12943-019-1099-7
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  publication-title: Cell.
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– volume: 6
  start-page: 580
  issue: 7
  year: 2020
  ident: 2171_CR4
  publication-title: Trends Cancer.
  doi: 10.1016/j.trecan.2020.02.003
– volume: 79
  start-page: 1285
  issue: 7
  year: 2019
  ident: 2171_CR8
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-18-2965
– volume: 23
  start-page: 262
  issue: 5
  year: 2017
  ident: 2171_CR1
  publication-title: Cancer J.
  doi: 10.1097/PPO.0000000000000281
– volume: 46
  start-page: 2844
  issue: 10
  year: 2017
  ident: 2171_CR2
  publication-title: Chem Soc Rev.
  doi: 10.1039/c6cs00599c
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Snippet Keywords: 5mC, m.sup.6A, Methylation regulator, Bladder cancer, Small-cell lung cancer, Immunotherapy response, Precision medicine
Background With the development of molecular biology techniques, it is possible to explore the tumorigenesis and cancer development mechanisms and intrinsic...
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StartPage 295
SubjectTerms 5mC
Acids
Biomarkers
Bladder cancer
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Chromosomes
DNA methylation
Drug therapy
Epigenetics
Gene expression
Genetic aspects
Genomes
Health aspects
Heterogeneity
Humans
Immunotherapy
Immunotherapy response
Lung cancer
Lung cancer, Small cell
m6A
Medical prognosis
Medical research
Methylation
Methylation regulator
Molecular biology
Neoplasms - drug therapy
Neoplasms - genetics
Nucleic acids
Phenotypes
Precision Medicine
Prognosis
RNA, Neoplasm - metabolism
Small-cell lung cancer
Transcriptomes
Tumorigenesis
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Title Models based on nucleic acid methylation regulators will contribute to facilitating cancer precision medicine
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