Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and transmission settings in The Gambia

• Published in: BMC medicine Vol. 18; no. 1; pp. 304 - 17
• Main Authors: Wu, Lindsey, Mwesigwa, Julia, Affara, Muna, Bah, Mamadou, Correa, Simon, Hall, Tom, Singh, Susheel K., Beeson, James G., Tetteh, Kevin K. A., Kleinschmidt, Immo, D’Alessandro, Umberto, Drakeley, Chris
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.09.2020; BioMed Central; BMC
• Subjects: Adolescent; Age; Antibodies; Antibody Formation - immunology; Antigens; Asymptomatic infection; Child; Child, Preschool; Clustering; Deoxyribonucleic acid; Diagnosis; Disease transmission; DNA; Dry season; E coli; Female; Gambia; Health aspects; Heat shock proteins; Hsp40 protein; Humans; Infections; Infectivity; Laboratories; Malaria; Malaria, Vivax - epidemiology; Male; Markers; Parasitic diseases; Plasmodium falciparum; Polymerase chain reaction; Polyvinyl alcohol; Prevalence; Prospective Studies; Proteins; Seasons; Seroepidemiologic Studies; Serology; Surveillance; Towns; Vector-borne diseases; Gambia; Malaria; Surveillance; Serology

As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission. Serological assays measuring malaria antibody responses offer a cost-effective detection method to supplement existing surveillance tools. A prospective cohort study was conducted f...