CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; pp. 120 - 23
• Main Authors: Chen, Dongni, Zhou, Hongli, Cai, Zhuochen, Cai, Kaican, Liu, Ji, Wang, Weidong, Miao, Huikai, Li, Hongmu, Li, Rongzhen, Li, Xiaodong, Chen, Youfang, Wang, Hui-Yun, Wen, Zhesheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.04.2022; BioMed Central; BMC
• Subjects: Analysis; Apoptosis; Biomarkers; Cancer therapies; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell cycle; Cell Cycle Proteins - metabolism; Cell Proliferation - genetics; CircSCAP; Flow cytometry; Humans; Kinases; Lung cancer; Lung cancer, Non-small cell; Lung cancer, Small cell; Lung Neoplasms - pathology; Medical prognosis; MicroRNAs; MicroRNAs - genetics; Mutation; Non-small cell lung cancer; p53; Patients; Phosphorylation; Prognosis; Protein binding; Proto-Oncogene Proteins - metabolism; Ribonucleoprotein, U2 Small Nuclear - metabolism; RNA; RNA, Circular - genetics; SF3A3; Tumor proteins; Tumor Suppressor Protein p53 - genetics; China; United States > US; SF3A3; CircSCAP; Prognosis; Non-small cell lung cancer; p53

Circular RNA (circRNA) has been recently identified as a critical regulator during carcinogenesis. However, the biological function and potential underlying mechanisms of circRNAs in lung cancer remain to be further elucidated. Here, we first evaluated the differentially expressed circRNAs between t...