Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

• Published in: Journal of hematology and oncology Vol. 14; no. 1; pp. 187 - 19
• Main Authors: Yu, Weina, Lei, Qingyang, Yang, Li, Qin, Guohui, Liu, Shasha, Wang, Dan, Ping, Yu, Zhang, Yi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.11.2021; BioMed Central; BMC
• Subjects: Animals; Cancer; Cell proliferation; Cholesterol; Cytokines; Cytotoxicity; Development and progression; Enzymes; Fatty acids; Genotype & phenotype; Glucose; Hematology; Humans; Hypoxia; Immune response; Immune system; Immunity; Immunotherapy; Lipid Metabolism; Lipids; Lymphocytes; Malignant tumor; Metabolism; Metabolites; Metastases; Metastasis; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - therapy; Oncology; Phenotypes; Physiological aspects; Review; Transcription factors; Transformed cells; Tumor cells; Tumor Escape; Tumor Microenvironment; Tumors; Canada; Immune response; Lipid metabolism; Malignant tumor; Tumor microenvironment; Immunotherapy

Complex interactions between the immune system and tumor cells exist throughout the initiation and development of cancer. Although the immune system eliminates malignantly transformed cells in the early stage, surviving tumor cells evade host immune defense through various methods and even reprogram...