Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells

• Published in: Biological research Vol. 52; no. 1; pp. 37 - 14
• Main Authors: Liu, Li, Fan, Jingyan, Ai, Guihai, Liu, Jie, Luo, Ning, Li, Caixia, Cheng, Zhongping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.07.2019; BioMed Central; BMC
• Subjects: Apoptosis; Berberine; Cancer cells; Caspase; Caspase-3; Caspase-8; Cell cycle; Cell death; Cell proliferation; Cell viability; Chemotherapy; Cholecystokinin; Cisplatin; Cytology; DNA damage; Dosage and administration; Drug therapy; Flow cytometry; Health aspects; Herbal medicine; Immunofluorescence; Kinases; Medical research; Medicinal plants; Necroptosis; Ovarian cancer; Physiological aspects; Plant extracts; Proliferating cell nuclear antigen; Testing; Transmission electron microscopy; Tumor cell lines; Western blotting; China; United States > US; Berberine; Necroptosis; Cisplatin; Apoptosis; Ovarian cancer

Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chemotherapeutic agent against cancer by inducing DNA damage and cell apoptosis. However, the e...