Flaxseed oil ameliorated high-fat-diet-induced bone loss in rats by promoting osteoblastic function in rat primary osteoblasts

• Published in: Nutrition & metabolism Vol. 16; no. 1; p. 71
• Main Authors: Chen, Fulian, Wang, Yan, Wang, Hongwei, Dong, Zhenhua, Zhang, Mengqi, Li, Jiaxuan, Shao, Shanshan, Yu, Chunxiao, Huan, Zhikun, Xu, Jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.10.2019; BioMed Central; BMC
• Subjects: Basketball players; Biomechanics; Bone biomechanics; Bone density; Bone growth; Bone loss; Bone mineral density; Bone resorption; Bones; Brain; Cancellous bone; Cbfa-1 protein; Collagen; Consumption; Cortical bone; Diet; Endocrinology; Fatty acids; Flaxseed oil; Fractures; Fractures (Geology); Genes; Health; Health aspects; High fat diet; Histology; Laboratory animals; Linolenic acid; Linolenic acids; Mechanical properties; Metabolism; Nutrition research; Omega 3 fatty acids; Osteoblasts; Osteogenesis; Osteoporosis; Palmitic acid; Plants; Prevention; Primary osteoblasts; Risk factors; Saturated fatty acids; Soybeans; Tensile strength; Unsaturated fatty acids; Vegetable oils; α-Linolenic acid; β-Catenin; China; Beijing China; Osteoporosis; Primary osteoblasts; Flaxseed oil; α-Linolenic acid; High-fat diet

α-Linolenic acid (ALA) is a plant-derived omega-3 unsaturated fatty acid that is rich in flaxseed oil (FO). The effect of FO on bone health is controversial. This study aims to evaluate the effect of FO on bone damage induced by a high-fat diet (HFD) and to explore the possible mechanism. Male Sprag...