Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; p. 282
• Main Authors: Laha, Dipranjan, Grant, Robert R C, Mishra, Prachi, Boufraqech, Myriem, Shen, Min, Zhang, Ya-Qin, Hall, Matthew D, Quezado, Martha, De Melo, Michelly Sampaio, Del Rivero, Jaydira, Zeiger, Martha, Nilubol, Naris
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.09.2022; BioMed Central; BMC
• Subjects: Adrenal Cortex Neoplasms - drug therapy; Adrenal Cortex Neoplasms - genetics; Adrenal Cortex Neoplasms - metabolism; Adrenocortical cancer; Adrenocortical Carcinoma - drug therapy; Adrenocortical Carcinoma - genetics; Adrenocortical Carcinoma - metabolism; Analysis; Animals; Apoptosis; beta Catenin; Cancer; Caspase 3; Cell cycle; Cell Line, Tumor; Cell Proliferation; Clinical trials; Cyclin-dependent kinase; Cyclin-Dependent Kinases; Cyclins; DNA binding proteins; Drug therapy, Combination; G2 Phase Cell Cycle Checkpoints; Gene expression; Genomics; Glycogen; Glycogen Synthase Kinase 3 - pharmacology; Glycogen Synthase Kinase 3 - therapeutic use; Humans; Kinases; Maternal embryonic leucine zipper kinase; Mice; Neuroendocrine tumors; Patients; Pharmaceuticals; Protein Serine-Threonine Kinases; Pyrazoles; Quantitative high-throughput screening; RNA; RNA, Messenger; Scientific equipment and supplies industry; Software; Stathmin; Synthesis; Targeted therapy; Tubulin; Tubulins; Tumors; Urea - analogs & derivatives; Vimentin; β-catenin; United States; United States > US; Cyclin-dependent kinase; Adrenocortical cancer; β-catenin; Quantitative high-throughput screening; Targeted therapy; Maternal embryonic leucine zipper kinase

Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their synergistic efficacy in ACC preclinical models. A quantitative high-throughput drug screenin...