Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways

• Published in: Cancer cell international Vol. 19; no. 1; pp. 329 - 13
• Main Authors: Ai, Jafar, Ketabchi, Neda, Verdi, Javad, Gheibi, Nematollah, Khadem Haghighian, Hossein, Kavianpour, Maria
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.12.2019; BMC
• Subjects: Cancer therapies; Cell adhesion & migration; Cell cycle; Cell growth; Cell migration; Cirrhosis; Cyclin-dependent kinases; Cytokines; Dkk1 protein; Drug resistance; Embryos; Genes; Hepatitis; Hepatocellular carcinoma; Inflammation; JNK pathway; Kinases; Ligands; Liver cancer; Liver cirrhosis; Liver diseases; Mesenchymal stem cells; Mesenchymal stromal cells; Mesenchyme; NF-κB protein; Nuclear factor-kappa B; Paracrine signalling; Proteins; Review; Signal transduction; Stem cells; Stromal cells; Telomerase; Toll like receptor; Toll-like receptors; Transcription factors; Transplants & implants; Trophic factors; Tumor cells; Tumorigenesis; Wnt protein; Wnt signaling; β-Catenin; JNK pathway; Nuclear factor-kappa B; Mesenchymal stromal cells; Hepatocellular carcinoma; Toll like receptor; Wnt signaling

Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver disease worldwide. Molecular changes in HCC collectively contribute to Wnt/β-catenin, as a tumor proliferative signaling pathway, toll-like receptors (TLRs), nuclear factor-kappa B (NF-κB), as well as the c-Jun NH2-terminal...